JaLCDOI 10.18926/AMO/41326
フルテキストURL 64_6_399.pdf
著者 Chang, Chin-Hsien| Chen, Kuo-Ti| Lee, Tsong-Hai| Wang, Chao-Hung| Kuo, Yi-Wen| Chiu, Ya-Huang| Hsieh, Ching-Liang| Wu, Chang-Jer| Chang, Yen-Lin|
抄録 Vascular endothelial damage has been found to be associated with thrombus formation, which is considered to be a risk factor for cardiovascular disease. A diet of natto leads to a low prevalence of cardiovascular disease. The aim of the present study was to investigate the effects of natto extract on vascular endothelia damage with exposure to laser irradiation. Endothelial damage both in vitro and in vivo was induced by irradiation of rose bengal using a DPSS green laser. Cell viability was determined by MTS assay, and the intimal thickening was verified by a histological approach. The antioxidant content of natto extract was determined for the free radical scavenging activity. Endothelial cells were injured in the presence of rose bengal irradiated in a dose-dependent manner. Natto extract exhibits high levels of antioxidant activity compared with purified natto kinase. Apoptosis of laser-injured endothelial cells was significantly reduced in the presence of natto extract. Both the natto extract and natto kinase suppressed intimal thickening in rats with endothelial injury. The present findings suggest that natto extract suppresses vessel thickening as a synergic effect attributed to its antioxidant and anti-apoptosis properties.
キーワード laser irradiation natto extract thrombolysis thrombosis
Amo Type Original Article
発行日 2010-12
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 399
終了ページ 406
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21173810
Web of Science KeyUT 000285664200007