JaLCDOI 10.18926/AMO/30961
フルテキストURL fulltext.pdf
著者 Soto-Gutierrez, Alejandro| Navarro-Alvarez, Nalu| Caballero-Corbalan, Jose| Tanaka, Noriaki| Kobayashi, Naoya|
抄録 <p>Hepatic and pancreatic differentiation from ES cells is of great interest for the impact that this knowledge could have on the treatment of hepatic and diabetic patients. The liver and pancreas initially develop by budding from the embryonic endoderm. Thus, the development of the endoderm represents an important step and has an integral common role in initiating the early stages of pancreatic and liver development. We know that the development of hepatocytes and insulin-producing pancreatic beta-cells from ES cells represents the culmination of a complex developmental program. However, there has been recent progress in directing ES cells to endoderm and early-stage hepatic and pancreatic progenitor cells. We here discuss the role of the microenvironment, transcriptional factors and cytokines, which have been recognized as important molecules during the major steps of the development of the liver and pancreas. We also present the most recent advances and efforts taken to produce definitive endoderm-committed ES cells for the further differentiation of hepatocyte-like and insulinproducing cells. Recent progress in the search for new sources of hepatocytes and beta-cells has opened up several possibilities for the future of new perspectives for future of new prophylactic and therapeutic possibilities for liver diseases and diabetes.</p>
キーワード embryonic stem cells (ES cells) diff erentiation hepatocyte like-cells insulin-producing cells defi nitive endoderm
Amo Type Review
発行日 2008-04
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 63
終了ページ 68
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 18464881
Web of Science KeyUT 000255297600001