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ID 16031
Eprint ID
16031
フルテキストURL
Thumnail 100_939.pdf 2.59 MB
タイトル(別表記)
Studies on the role of the kallikrein-kinin system in bronchial asthma Part 2. Determination of kallikrein-like activity in bronchoalveolar lavage fluid
著者
髙井 豊 岡山大学医学部第二内科学教室
抄録
Kallikrein-like activity was evaluated in the bronchoalveolar lavage fluid (BALF) of 43 patients (33 bronchial asthma patients and 10 controls) to study the inflammatory response in the lower respiratory tract of asthma patients. The appearance rate of BALF kallikrein-like activity (BKLA) was 25.0% in asthmatics, and 60.0% in asthmatics after provocation by a specific antigen, whereas it was negative in healthy subjects. The increase in BKLA in asthmatic subjects was significant. BKLA in patients with an immediate asthmatic response after provocation turned negative, whereas it was positive in their ordinary BALF. On the contrary, BKLA after provocation in those with a late asthmatic response turned positive, whereas it was negative in their ordinary BALF.Characterization using three protease inhibitors indicated that BKLA had an enzymatic character similar to plasma kallikrein. These results suggest that the activation of the kallikrein-kinin system may have a possible role during anaphylaxis in asthmatics.
キーワード
bronchial asthma
bronchoalveolar lavage fluid
kallikrein-like activity
neutrophils chemotaxis
immediate and late asthmatic response
発行日
1988
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
100巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
939
終了ページ
950
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/100/9-10/100_9-10_939/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma