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ID 16028
Eprint ID
16028
フルテキストURL
Thumnail 100_927.pdf 699 KB
タイトル(別表記)
Studies on the role of the kallikrein-kinin system in bronchial asthma Part 1. Relationship between bronchial asthma and Hageman factor dependent pathways
著者
髙井 豊 岡山大学医学部第二内科学教室
抄録
The relationship between bronchial asthma and Hageman factor dependent pathways (the contact phase of the internal coagulation system) was studied in reference to the possible role of the kallikrein-kinin system in asthmatics.The plasma Hageman factor level was significantly lower in asthmatics (74.8±27.7% in remission, and 75.4±26.3% during in attack) than in healthy subjects (98.1±27.6%), and the plasma prekallikrein value was also lower in asthmatics (88.8±25.3% in remission, and 75.1±23.8% during in attack) than in normal controls (105.7±19.7%). Especially, the plasma prekallikrein level was significantly lower in asthmatics during in attack than in those in remission. The plasma bradykinin level of asthmatics in remission tended to be higher (98.8±89.8pg/ml) than that of healthy subjects (47.1±29.6pg/ml). The plasma high molecular weight kininogen level was not significantly different between asthmatics and normal subjects. These results suggest that the plasma kallikrein-kinin system may play a role in the pathophysiology of bronchial asthma.
キーワード
bronchial asthma
Hageman factor dependent pathways
kallikrein-kinin system
atopic asthma
intractable asthma
発行日
1988
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
100巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
927
終了ページ
937
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/100/9-10/100_9-10_927/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma