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ID 11681
Eprint ID
11681
フルテキストURL
Thumnail K003304.pdf 72.2 KB
タイトル(別表記)
ホルムアルデヒドガスに曝露された医学生における臨床症状と皮膚試験反応についての前向き研究
著者
髙橋 祥子 岡山大学
抄録
Previous investigators have reported the occurrence of both allergic and non-allergic systemic complications due to exposure to formaldehyde gas. However, little is known about the pathogenic link between formaldehyde-induced clinical symptoms and patch test results, or about the long-term effects of formaldehyde exposure. In the present study, a questionnaire was administered to 143 medical students, and 60 of them were tested by patch test for formaldehyde at the beginning and end of a human anatomy laboratory course. Another group of 76 students who had finished the course 2-4 years previously were administered another questionnaire, and the patch test was carried out on 58 of them. The frequencies of skin irritation, eye soreness, lacrimation, eye fatigue, rhinorrhea, throat irritation, general fatigue and mood swings increased after repeated exposure. Two (3.3%) of 60 students became positive to 1% formaldehyde at the end of the anatomy course (one male with allergic hand dermatitis due to direct contact with formaldehyde, and one female with an atopic background with unbearable physical symptoms) while the remaining 58 showed a negative reaction throughout the study period. The vast majority of students complained of various non-allergic, physical symptoms, and recovered from such symptoms without subsequent complications. No progression to multiple chemical sensitivity was found. Students with an episode of atopic dermatitis and allergic rhinitis were susceptible to formaldehyde exposure, and developed mucocutaneous symptoms, probably due to the impaired barrier function and remodeling of the skin and mucosa.
キーワード
barrier function
multiple chemical sensitivity
formaldehyde
patch test
prospective and follow-up study
備考
http://dx.doi.org/10.1111/j.1346-8138.2007.00274.x
発行日
2007-03-23
出版物タイトル
資料タイプ
学位論文
学位授与番号
甲第3304号
学位授与年月日
2007-03-23
学位・専攻分野
博士(医学)
授与大学
岡山大学
オフィシャル URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17408435&dopt=Abstract
言語
Japanese
論文のバージョン
none
査読
不明