JaLCDOI 10.18926/fest/11542
タイトル(別表記) Preparation and In Vitro Release Property of PLA Microspheres Enclosing Antitumor Agent
フルテキストURL 006_103_106.pdf
著者 西野 悟| 吉澤 秀和| 夏越 祥次| 愛甲 孝| 幡手 泰雄| 北村 吉朗|
抄録 Recently, many antitumor agents developed. Irinotecan hycrochloride (CPT) has a great side effect even though it is well effective against the cancer. Drug delivery system (DDS) medicine indicates that the release rate of medicine is constant for a long time. Therefore, in order to materialize the general idea of DDS, we applied microencapsulation technique to prepare biodegradable polymer microspheres (MS) enclosing antitumor drug having no side effect. Polylactide microparticles enclosing antitumor agent were prepared by solvent evaporation method under various operation conditions. The effects of operation parameter on release rate of drug and morphology of microparticles were studied.
キーワード DDS microparticle polylactide antitumor agent solvent evaporation DSC
出版物タイトル 岡山大学環境理工学部研究報告
発行日 2001-02-28
開始ページ 103
終了ページ 106
ISSN 1341-9099
言語 Japanese
論文のバージョン publisher
NAID 120002314051
著者 西野 悟|
発行日 2005-03-25
資料タイプ 学位論文