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ID 16330
Eprint ID
16330
フルテキストURL
Thumnail 95_583.pdf 5.11 MB
タイトル(別表記)
Effect of BCG and Levamisole on peritoneal invasion of cancer: experimental study in mice.
著者
西原 幸一 岡山大学医学部第一外科教室
抄録
An insight into the mechanism of cancer invasion through the serosa of digestive organs has not been obtained since an adequate experimental model has not been found. In this report, the mouse abdominal wall was considered as intestinal wall and the invasive pattern of cancer cells into the peritoneum was examined morphologically by means of scanning election microscopy (SEM). The effects of BCG and Levamisole (LMS) on the invasion and growth of cancer were also studied. When Ehrlich ascites tumor cells were implanted into the subcutaneous layer of the abdominal wall, the mesothelial cells became round, and the intercellular space expanded 7 days after the implantation. The tumor cells invaded the intercellular space by the 10th day. The mesothelial microvilli became dence and formed a meshwork 7 days after the tumor implantation in combination with an interperitoneal injection of BCG, resulting in firm intercellular binding. The condition was much more obvious on the 10th day. The enhancement of intercellular binding by BCG may play a role in preventing peritoneal invasion. Administering BCG before tumor implantation was better in preventing than administering it after the implantation. The most effective way was to administer BCG before the implantation, followed by two times a week from the 3rd day after the implantation. When LMS was used, the microvilli became quite dence, but not as much as with BCG. With administration of LMS from the 14th day after tumor implantation regression of tumor growth occurred, although the efficacy of LMS was less than that of BCG.
キーワード
漿膜浸潤
走査電顕
BCG
Levamisole
発行日
1983-08-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
583
終了ページ
600
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/7-8/95_7-8_583/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma