このエントリーをはてなブックマークに追加
ID 14639
Eprint ID
14639
フルテキストURL
Thumnail 078_649.pdf 1010 KB
著者
西風 桂子 岡山大学医学部病理学教室
抄録
The mitochondria isolated from ascites tumor cells have a specific characteristic different from those isolated from normal liver cells, i. e. they do not react with ferrous ion, GSH with GSSG and ascorbic acid, showing no increase in lipid peroxide formation and no swelling. From the viewpoint that this characteristic of tumor cell mitochondria may be due to the specific liqid. compositions of mitochondrial membrane, the author tried to analyze the components of liqids of tumor cells comparing with those of brain, liver, heart, kidney and spleen from normal animals. The following have been revealed; 1. The tumor cells are very low in peroxide formation in the presence of the reducing agents comparing to those from the normal tissues, though the grade of peroxide formation is different in each tissues and by the agents used, and is rather lower in homogenate than in intact mitochondria. 2. Chemical analysis revealed that the lipids from tumor cells is low in unsaturated fatty acid contents, especially C20-polyene contents than those from normal cells. This will be responsible for the low level in lipid peroxidation of the tumor cells. 3. On the basement of the these results discussions has been made on the lipid peroxidation of mitochondria of tumor cells and related mitochondrial swelling under the consideration of enzymic activities.
備考
学位番号 乙第230号
発行日
1966-05-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
78巻
4-5号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
649
終了ページ
654
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/78/4-5/78_4-5_649/_article/-char/ja/
関連URL
http://eprints.lib.okayama-u.ac.jp/4454/
http://eprints.lib.okayama-u.ac.jp/14636/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma