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ID 18350
Eprint ID
18350
フルテキストURL
Thumnail 74_255.pdf 5.09 MB
タイトル(別表記)
The New Quantitative Method of Hippuric Acid in The Urine of Workers after Exposure to Toluene
著者
緒方 正名 岡山大学医学部公衆衛生学教室
杉山 勝三 岡山大学医学部公衆衛生学教室
黒田 泰生 岡山大学医学部公衆衛生学教室
抄録
Hippuric acid excretion in the urine of workers after exposure to toluene, was assayed by a modified method of Gaffney's. The results obtained are as follows, 1) The determination of hippuric acid in the urine was carried out by paperchromatography, and 0.1 ml urine was spotted on the filterpaper (40×40cm), developed in the solvent system: buthanol-acetic acid-water, 4:1:1. After drying, the color reaction was brought to completion by spraying with 4 per cent solution of p-dimethylaminobenzaldehyde in acetic anhydride saturated sodium acetate and by heating it in a drying oven for one minute at 135℃. The R(f) value of hippuric acid contained in the urine was 0.8, and it coincided with that of pure hippuric acid, and the absorption spectrum of the methanol eluate of the colored spot of the workers' urine corresponded with that of pure hippuric acid. 2) At the autotricycle factory using the mixture of toluene and benzene (4:1) as a solvent of glue, and also toluene as a component of thinner for spray, an increase of hippuric acid excretion in the urine of workers was recognized after exposure to the solvent gases. 3) In the plastic factory using toluene as a solvent, the group of workers exposed to 50 p.p.m. of toluene in air bad the excretion of the hippuric acid 3.4 times compared with that befor exposure, and the group exposed to 20p.p.m., 1.9 times. These results indicate that the excretion of hippuric acid in the urine is in direct proportion to the concentration of toluene in air.
発行日
1962-03-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
74巻
1-3号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
255
終了ページ
261
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/74/1-3/74_1-3_255/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma