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ID 16276
Eprint ID
16276
フルテキストURL
Thumnail 95_243.pdf 476 KB
タイトル(別表記)
Function of peripheral blood lymphocytes in patients with systemic lupus erythematosus. Part 2. Significance of null cells in B cell activation
著者
盛政 公明 岡山大学医学部第三内科学教室
抄録
Activation of B lineage cells in systemic lupus erythematosus(SLE) has been indicated by the synthesis of IgG without mitogenic stimulation. In the course of this study, a cell population in SLE peripheral blood which synthesized DNA spontaneously and which fractionated into a null cell population was noticed. It was found that cells responsible for hyperproduction of IgG without any stimulation in vitro belonged to the null cell population, not to the sIg(+) cell population. The data suggested that both spontaneous IgG production and DNA synthesis might be performed by the same cell population in SLE. To test whether or not secreted IgG was synthesized by preactivated SLE peripheral blood lymphocytes, these cells were stained with FITC-labeled anti-human Ig antibodies. Significantly more cytoplasmic Ig(+) staining in SLE cells than in normal cells was found. These observations suggest that there was a small group of cells of B cell lineage in the SLE peripheral blood which was stimulated to proliferate and differentiate into a sIg(-) plasmablast line able to secrete IgG.
キーワード
systemic lupus erythematosus
spontaneous Ig synthesis
B cell activation
null cell fraction
発行日
1983-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
243
終了ページ
251
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/3-4/95_3-4_243/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma