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ID 13840
Eprint ID
13840
フルテキストURL
Thumnail 106_1053.pdf 2.46 MB
タイトル(別表記)
The influence of inorgranic fluoride on the renal function in rabbits
著者
溝渕 知司 岡山大学医学部麻酔・蘇生学教室
抄録
Some of the halogenated inhalation anesthetics are metabolized partly in the liver to produce inorganic fluoride, and serum inorganic fluoride in continuous high concentration may cause renal dysfunction. In this study, the influence of elevated serum inorganic fluoride concentration and the duration of its action on renal function were studied by continuous infusion of sodium fluoride in rabbits for 24hours. The rabbits were divided into Control (group C), Low dose (group L) and High dose (group H) groups with mean serum inoganic fluoride levels of 1.9 μ M, 62.4 μ M and 237.7μ M, respectively. Twinty-four hour total urine volume increased in group H compared to group C. Urinary excretion of β2-microgloblin (β(2)MG), leucine aminopeptidase (LAP) and N-acetyl-β-D-glucosaminidase (NAG), collected every 6 hours, increased significantly in group H within 0~6 hours, whereas LAP increased within 18~24 hours and NAG within 12~18 hours in group L, compared to group C. The area under the curve of serum inorganic fluoride concentration, when the increase of NAG (the earliest among β(2)MG, LAP and NAG) excretion was detected (6 hours in group H, 18 hours in group L), were similar (group H ; 1272±165 μ M・hours, group L ; 1197±189 μ M・hours). Free water clearance over 24 hours increased significantly in group H only. Morphological examination showed the absence of the brush border and that cellular damage had occurred in the renal tubules in both group L and group H. These findings were more apparent in group H. In conclusion, it was revealed that not only the elevated serum inorganic fluoride concentration but also its duration were the factors inducing renal dysfunction, beginning with proximal tubuar damage and subsequently developing to decreased water reabsorption.
キーワード
血清無機フッ素濃度
腎障害
β-N-アセチルグルコサミニダーゼ (NAG)
自由水クリアランス (C(H(2)O))
時間的検討
備考
原著
発行日
1994-10
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
106巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1053
終了ページ
1061
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/106/9-10/106_9-10_1053/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
Copyright© 岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma