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ID 40789
フルテキストURL
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タイトル(別表記)
Studies of guanidinoethanesulfonic acid induced convulsions - Effect of guanidinoethanesulfonic acid on monoamines in the mouse brain -
著者
渡辺 駿二 岡山大学医学部脳代謝研究施設機能生化学部門教室
抄録
Guanidinoethanesulfonic acid (GES) is known to induce convulsive seizures when administered intracisternally into rabbits and cats. I examined the effects of GES on behavior, electroencephalogram and brain monoamine levels after intraventricular injection into mice. When GES was intraventricularly injected into mice, focal clonic movements of the face, vibrissae and ears, as well as twitchings of limbs were observed 0.5-1 min after injection. Hypersensitivity was observed until 7 min after the injection, after which the mice behaved in a normal way. It is also observed that GES induced sporadic spike discharges in the electroencephalogram. The latency and duration of the appearence of spike discharges showed considerable individual variation. The latency was from 0 to 5 min, and the duration was from 5 to 90 min. No spike discharge was observed in the saline injected animals. The 5-hydroxytryptamine (5-HT) level decreased in the hippocampus, diencephalon, pons-medulla oblongata and cerebellum 5 min after injection, and recovered to the control level 10 min after the injection. No change in the norepinephrine (NE) and dopamine (DA) levels was found after GES injection. 5-hydroxyindoleacetic acid increased in the striatum and cerebellum 5 min after injection. It is thought that the GES injection enhances the release of 5-HT in the striatum and cerebellum, although the mechanism of the decrease of 5-HT in the hippocampus, diencephalon and pons-medulla oblongata is unclear. These results indicate that the GES induced convulsive seizure is related to 5-HT neurons, not NE or DA neurons.
キーワード
guanidinoethanesulfonic acid
convulsion
brain monoamines
5-hydroxytryptamine
発行日
1989-12
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
101巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
977
終了ページ
989
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/101/11-12/101_11-12_977/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma