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ID 17725
Eprint ID
17725
フルテキストURL
Thumnail 86_107.pdf 4.64 MB
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タイトル(別表記)
Studies on Comparison of Lipid Metabolism in Whole Blood Cells and Liver Part I. The Effect of Acute Carbon Tetrachloride Intoxication on Lipid Metabolism
著者
河内 光男 岡山大学医学部第二内科
抄録
The present study was designed to investigate some role of whole blood cells in lipid metabolism compared to that of liver in acute carbon tetrachloride intoxicated rats. In order to determine this, in vitro incorporation of (14)C-acetate Na into gross lipid fractions, major lipid fractions and total fatty acids was studied. The experimental animals employed were male Wistar rats, which were subjected to subcutaneous injection of 50% CCl4 in olive oil, 0.2ml/100gm. of body weight. Animals were sacrificed at time intervals of 4 and 48 hours following treatment. The results obtained are summarized as follows: 1) (14)C incorporation by liver slices into total lipids, unsaponifiable lipids and total fatty acids was markedly decreased at 4 hours, but at 48 hours it was strikingly increased in accordance with liver cell regeneration. On the other hand, (14)C incorporation by whole blood cells into each of them showed a trend toward an increase at 4 hours, although there were few differences between carbon tetrachloride administered rats and controls at 48 hours. 2) Percent (14)C incorporation by liver slices into TG and NEFA increased significantly following CCl(4) treatment, while whole blood cells incorporated relatvely more radioactivity into NEFA than that of controls. Consequently it is considered that fatty liver would be caused by enhancement of TG and NEFA synthesis in liver, and at the same time lipid metabolism in whole blood cells would contribute to fatty liver. 3) In acute CCl(4) intoxication of rats, a decrease of percent (14)C incorporation by liver slices into fatty acid group 14:0+16:0, namely the decreased activity of malonyl CoA pathway was observed, while that into 20 carbons and more longer chains, fatty acids, formed via mitochondrial pathway, showed a significant relative increase; the results being similar to those observed with whole blood cells.
備考
正誤表あり
発行日
1974-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
86巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
107
終了ページ
115
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/86/3-4/86_3-4_107/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma