著者 松原 扶美恵| 周藤 真康| 谷崎 勝朗| 森永 寛|
発行日 1987-08
出版物タイトル 環境病態研報告
58巻
資料タイプ データ・データベース
著者 井上 妙子| 谷崎 勝朗| 森永 寛|
発行日 1986-07
出版物タイトル 環境病態研報告
57巻
資料タイプ データ・データベース
JaLCDOI 10.18926/19678
タイトル(別表記) Spa therapy for bronchial asthma. Annual changes of characteristics of asthmatics admitted during the past four years.
フルテキストURL 057_037_041.pdf
著者 谷崎 勝朗| 周藤 真康| 駒越 春樹| 森永 寛|
抄録 1982年1月から1985年12月までの4年間に三朝分院内科へ入院し,温泉療法を受けた気管支喘息45例を対象にその年次推移を検討した。1.性別:初期2年間は男性の入院症例が多い状況であったが,後期2年間では男女比はほぼ等しかった。2.年令:年次推移はみられず,その平均年令は50±2才の間にあった。3.地域分布:初期2年間は岡山県からの入院症例が多数をしめたが,後期2年間ではむしろ鳥取県からの入院症例が増加する傾向がみられた。4.入院期間:初期2年間の平均入院期間は6.7カ月,6.5カ月とかなり長くなる傾向がみられたが,後期2年間ではそれぞれ3.0カ月,1.5カ月と明らかな短縮傾向がみられた。5.臨床病型:いずれの年度においても重症化傾向の強いⅠb型,Ⅱ型が多くみられたが,各年度間には差はみられなかった。6.ステロイド剤使用状況:年度の経過とともにその使用量は減少して いく傾向が示された。
抄録(別表記) Annual changes of characteristics, sex, area (Prefecture) of patients' coming from, term of admission, clinical classification of asthma and use of glucocorticoids, were examined in 45 patients with bronchial asthma who were admitted at Misasa Hospital, Okayama University Medical School and received spa therapy during the past four years from 1982 to 1985. In the first two years from 1982 to 1983, more patients with bronchial asthma were admitted from Okayama Prefecture, and the majority of them had severe asthma attacks and were more dependent on steroid-therapy. On the other hand, in the past two years from 1984 to 1985, number of patients with bronchial asthma from Tottori Prefecture increases, and their attacks were less severe and less dependent on steroid-therapy compared to the patients admitted during the first two years. Term of admission became shorter in the past two years than in the first two years. Any differences between the first and the past two years were not shown in sex, patient age and asthma types classified by clinical symptoms.
キーワード 気管支喘息 (Bronchial asthma) 温泉療法 (spa therapy) 臨床病型 (asthma type)
出版物タイトル 環境病態研報告
発行日 1986-07
57巻
開始ページ 37
終了ページ 41
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002309135
JaLCDOI 10.18926/19662
タイトル(別表記) Effect of aging on pancreatic exocrine function -Aging and fecal chymotrypsin activity-
フルテキストURL 057_024_028.pdf
著者 松本 秀次| 原田 英雄| 越智 浩二| 武田 正彦| 田中 淳太郎| 森永 寛| 吉田 光雄| 木村 郁郎|
抄録 膵外分泌機能に及ぼす加齢の影響を検討する目的で,健常人43名,非膵疾患患者41名,老人ホーム入居者39名を対象として比色法により糞便中キモトリプシン活性(FCA)を測定し,以下の結論を得た。1)FCAは逐齢的に低下し,60歳以上は60歳未満より有意の低値を示した。しかし,分布図のretrospectiveな検討からは,膵外分泌機能の低下は,実際には65~70歳あたりから明らかになることが示唆された。2)FCAの正常下限値を14.5U/gに定めたが,高齢者の診療にあたってはこの正常値のみを根拠にして疾病の有無を判定すべきではない。3)老人ホーム入居者のFCAは特に低値を取ったがその主要因は高齢者が多いためと考えられた。
抄録(別表記) To examine the effect of aging on the pancreatic exocrine function, fecal chymotrypsin activity (FCA) was measured by the photometric method in 43 healthy controls, 39 controls in an old-age home and 41 patients with non-pancreatic diseases. Following conclusions were obtained. 1) Pancreatic exocrine function showed a significant decrease with aging as indicated by the present prospective study : ① a significantly lower FCA in the B group of 22 healthy controls (≧ 60 years of age) than the A group of 21 healthy controls (< 60 years of ago) ; ② significant correlationship between aging and FCA in the 43 healthy controls and also in the 41 patients with non-pancreatic diseases. 2) FCA in controls in an old-age home was especially low. Presumably it was due to their far-advanced aging. 3) The calculated lower limit of normal in FCA was 14.5U/g. However, the diagnosis of pancreatic diseases should not be coined solely on the basis of decreased FCA value.
キーワード 糞便中キモトリプシン活性 (Fecal chymotrypsin activity) 加齢 (Aging) 膵外分泌機能 (Pancreatic exocrine function) 膵 (Pancreas) 酵素 (Enzyme)
出版物タイトル 環境病態研報告
発行日 1986-07
57巻
開始ページ 24
終了ページ 28
ISSN 0913-3771
言語 Japanese
論文のバージョン publisher
NAID 120002309096
JaLCDOI 10.18926/19683
タイトル(別表記) Studies on anti-allergic actions of tranilast (Rizaben®)
フルテキストURL 057_042_045.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 森永 寛| 大谷 純| 木村 郁郎|
抄録 抗アレルギー剤(脱顆粒抑制剤)の1つであるtranilastの肥満細胞の遊離機序に対する抑制作用について検討を加えた。1.抗原刺激時の肥満細胞の(45)Ca uptakeおよびヒスタミン遊離に対して,tranilastは有意の抑制作用を示したが,comp.48/80刺激時にはtranilastの(45)Ca uptake,ヒスタミン遊離に対する抑制作用はほとんどみられなかった。2.phosphatidylserine添加時には,(45)Ca uptakeに対するtranilastの抑制作用は減弱傾向を示し,この傾向はヒスタミン遊離に対する作用に比べより高度であった。3.抗原および抗ヒトIgEによる好塩基球からのヒスタミン遊離に対して,tranilastは明らかな抑制作用を示さなかった。
抄録(別表記) Tlanilast is clinically used for bronchial asthma as one of the prophylactic agents for asthma attacks. In this study, anti-allergic actions of tranilast were examined in (45)Ca uptake of and histamine release from target cells of IgE after stimulation with antigen, anti-IgE and camp. 48/80. 1. (45)Ca uptake of and histamine release from rat peritoneal mast cells stimulated by antigen were significantly inhibited by preincubation of the cells with tranilast. Inhibition by tranilast of increased (45)Ca uptake of mast cells by addition of phosphatidylserine were less, although inhibition of histamine release was not so affected by addition of phosphatidylserine. No significant inhibition by tranilast of (45)Ca uptake and histamine release was not observed when the cells were stimulated by camp. 48/80. 2. Tranilast showed any inhibitory effects on basophil histamine release induced by antigen and anti-IgE.
キーワード トラニラスト (tranilast) (45)Ca取り込み ((45)Ca uptake) ヒスタミン遊離 (histamine release) 肥満細胞 (mast cell) 好塩基球 (basophils)
出版物タイトル 環境病態研報告
発行日 1986-07
57巻
開始ページ 42
終了ページ 45
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002308998
JaLCDOI 10.18926/21079
タイトル(別表記) Radioactivity and chromosome aberrations of residents of Misasa Spa
フルテキストURL pitsr_056_001_004.pdf
著者 森永 寛| 御船 政明| 古野 勝志|
抄録 Misasa Spa is one of the most highly radioactive hot springs in Japan, the waters of which contain mainly (222)Rn (437±132 Bq/liter). Radon contents of indoor air of private houses and health resort hotels (built of wood) at Misasa Spa range from 18.5 to 55.5 mBq/liter and 22.2 to 129.5 mBq/liter, respectively. Radon contents in the air of facilities using spring waters at Misasa Branch Hospital of Okayama University were measured to be ; bathroom 807±78 mBq/liter; Hubbardtank bathroom 5306±2568 mBq/liter ; the drinking hall 1491±178 mBq/liter. The environmental and dose rate inside private houses has been measured to be 14.0±1.8 μR/h. Chromosome aberrations (dicentrics) in the peripheral blood lymphocytes of residents of Misasa Spa were investigated in 14 persons; the mean value of aberration frequencies were 0.21%.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 1
終了ページ 4
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311024
JaLCDOI 10.18926/21086
タイトル(別表記) Effect of serial bathing on circadian variation of plasma metabolites in rats
フルテキストURL pitsr_056_035_043.pdf
著者 妹尾 敏伸| 原田 英雄| 御船 政明| 森永 寛|
抄録 The effect of serial bathing (10-minute bathing in city water or Misasa hot spring, 40℃, once daily for one or four weeks) on the circadian variations of plasma metabolites was studied in three groups of rats : hot spring bathing rats, city water bathing rats and non-treated rats. Plasma obtained by decapitation at 8:00, 12:00, 16:00, 20:00 and 24:00 hours was analysed for catecholamines (CA), free fatty acids (FFA), cholesterol (C) and glucose. 1) Noradrenaline (NA) and adrenaline (A) were significantly lower at 24:00 hours with significantly lower 24-hour average concentrations and also with significantly different diurnal patterns in the 1-week hot spring bathing rats; in the 4-week hot spring bathing rats, lower 24-hour average concentrarion of A was the only significant finding. The results suggest the suppressive effect of hot spring bathing on the sympathetic system or pituitary gland-adrenal medulla; they also suggest the adaptation to hot spring bathing. 2) Free fatty acids were significantly higher in the 1-week hot spring bathing rats at 12:00 hours as compared with non-treated rats and city water bathing rats. The 4-week hot spring bathing rats showed concentration of FFA not different from the remaining two groups of rats. No significant difference was noted in diurnal patterns among the three groups of rats. The results suggest that the high FFA concentrations in the 1-week hot spring bathing rats are related to the physico-chemical constituents of the hot spring to some extent and that the rats adapt themselves to bathing during the 4-week preriod. 3) Cholesterol was significantly lower in the 4-week hot spring bathing rats as compared with non-treated rats and city water bathing rats; no different diurnal patterns were noted among the three groups of rats. The results suggest the suppressive effect of 4-week hot spring bathing on plasma cholesterol concentrations as reported previously by us. 4) No Significant difference was noted in concentrations as well as in diurnal patterns of plasma glucose among the three groups of rats. The results suggest that bathing has no significan effect on concentrations and diurnal patterns of plasma glucose in healthy rats.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 35
終了ページ 43
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310969
JaLCDOI 10.18926/21084
タイトル(別表記) Spa therapy for patients with chronic obstructive lung disease
フルテキストURL pitsr_056_023_026.pdf
著者 周藤 眞康| 駒越 春樹| 谷崎 勝朗| 森永 寛|
抄録 During last three years, 41 patients with chronic obstructive lung disease (39 cases with bronchial asthma and 2 cases with chronic bronchiolitis) received spa therapy at Department of Medicine, Okayama University Medical School, Misasa Medical Branch. 1. Twenty three (56%) out of 41 cases came from Okayama prefecture and 10 cases (24.4%) from Tottori prefecture for spa therapy. In twenty five (61.0%) out of 41 cases, their ages were over 50 years. 2. Thirty nine patients with bronchial asthma were divided into three asthma types classified by clinical symptoms : Ia ; 16 cases (41.0%), Ib; 13 cases (33.3%) and II ; 10 cases (25.7%). Pulmonary function tests for these patients showed that small airways obstruction was most remarkable in type II asthma. 3. The mean serum IgE level of all asthmatic patients (39 cases) was 653.9U/ml. In skin test by allergens, positive immediate skin reaction was shown in 18 cases (46.2%) by Candida and 12 cases (30.8%) by house dust. Specific IgE anti-bodies were found in 9 cases (23.1%) for house dust and 3 cases (7.7%) for Candida.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 23
終了ページ 26
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311025
JaLCDOI 10.18926/21083
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 5.臨床的評価
フルテキストURL pitsr_056_017_021.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 森永 寛|
抄録 過去3年間にわたり,気管支喘息患者末梢血好塩基球からのヒスタミン遊離について,ヒスタミン自動分析装置を用いて全血法により検討を加えてきた. 1. 抗ヒトIgE によるヒスタミン遊離は,症例間で著しい差がみられた. この際血清IgE値が高値を示す症例では全般的に高度なヒスタシソ遊離がみられたが,血清IgE値が正常かまたはむしろ低値を示す症例のヒスタミン遊離は,かなり高度なものから全くみられないものまでさまざまであった. 2.ハウスダストやカンジダなどの抗原物質によるヒスタミン遊離は,特異的IgE抗体依存性であり,抗体価が上昇するにつれヒスタミン遊離は高度となる傾向がみられた. しかし,ハウスダストとカンジダによるヒスタミン遊離には若干の差がみられた. すなわち,ハウスダストと抗ヒトIgE によるヒスタミン遊離の間には密接な関連がみられたが,カンジダと抗ヒトIgEの間には全く関連がみられなかった. またカンジダによるヒスタミン遊離においては,IgE系反応以外の反応が関与する可能性が一部示唆された.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 17
終了ページ 21
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310985
JaLCDOI 10.18926/21094
タイトル(別表記) Spa therapy for patients with chronic obstructive lung disease
フルテキストURL pitsr_055_001_006.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 中郷 実雄| 森永 寛| 大谷 純| 木村 郁郎|
抄録 Thirty-six patients with chronic obstructive lung disease (34 cases with bronchial asthma, one case with chronic bronchiolitis and one case with pulmonary emphysema) have received spa therapy. Clinical effects of sa therapy on patients with bronchial asthma depended on patient age and asthma types classified by allergic reactions and clinical symptoms. Spa therapy was effective in the cases with ages more than 31 years and the cases with non-atopic type of bronchial asthma. Regarding asthma type classified by clinical symptoms, spa therapy was more effective in the cases with bronchiolar obstructive type and the cases with bronchospasm + hypersecretion type than in the cases with bronchospasm type of bronchial asthma.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-11-30
55巻
開始ページ 1
終了ページ 6
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311032
JaLCDOI 10.18926/21095
タイトル(別表記) Spa therapy for patients with chronic obstructive lung disease
フルテキストURL pitsr_055_007_010.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 森永 寛| 貴谷 光| 中川 三郎| 木村 郁郎|
抄録 Histamine releasse from basophils induced by house dust and C. albicans was examined in 30 patients with bronchial asthma. House dust and C. albicans caused a significant amount of histamine release in subjects with a RAST score to corresponding allergen. A close correlation was found between house dust- and anti-IgE-induced histamine release. However, histamine release induced by C. albicans was considerably different from the release induced by anti-IgE.
抄録(別表記) ハウスダストあるいはカンジダが特異抗原である気管支喘息30例を対象に,それぞれの抗原刺激時の好塩基球からのヒスタミン遊離を,抗ヒトIgEによる遊離と比較検討した. 1. ハウスダストが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時41.8%,抗ヒトIgE刺激時40.8%であった. 2. カンジダが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時27.1%,抗ヒトIgE刺激時32.2%であった. 3. ハウスダストと抗ヒトIgEによる好塩基球からのヒスタミン遊離は,ほぼ同様の値を示した. 一方カンジダと抗ヒトIgEによるヒスタミン遊離の間には有意の 相関関係はみられなかった.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-11-30
55巻
開始ページ 7
終了ページ 10
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310939
著者 井上 妙子| 谷崎 勝朗| 森永 寛|
発行日 1984-11-30
出版物タイトル 岡山大学温泉研究所報告
55巻
資料タイプ データ・データベース
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 中郷 実雄| 森永 寛| 大谷 純| 多田 慎也| 高橋 清| 木村 郁郎|
発行日 1984-04-30
出版物タイトル 岡山医学会雑誌
96巻
3-4号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/21104
タイトル(別表記) Effects of serial bathing on fatty acid composition of adrenal and serum cholesterol ester in rats
フルテキストURL pitsr_054_019_024.pdf
著者 妹尾 敏伸| 原田 英雄| 御船 政明| 森永 寛|
抄録 The effects of serial bathing (10 minutes bathing in a city water or hot spring in Misasa, 40℃, once daily for 1-4 weeks) on fatty acid composition of cholesterol ester of the adrenal glands and serum was studied in both normal and hypercholesteremic rats. Although the adrenal cholesterol ester levels were relatively unaffected in rats treated with serial bathing as well as non-treated rats, the proportion of 18 : 2 was increased in rats treated with hot spring bathing for 3-4 weeks. The serum cholesterol ester levels in both normal and hypercholesteremic rats tended to decrease after serial bathing for 3-4 weeks compared with non-treated rats. The fatty acid composition of serum cholesterol ester in normal rats was unaffected. The composition in hypercholesteremic rats showed an increase in the proportion of 16 : 1 and 18 : 1 and a decrease of 18 : 2 and 20: 4 compared with normal rats. When those of hypercholesteremic rats were treated with serial bathing for 3 weeks, particularly with hot spring bathing, the proportion of 16 : 1, 18: 2 and 20 : 4 showed a tendency to approach that in tormal rats. The findings indicate that serial hot spring bathing for 3-4 weeks, unlike city water bathing, exerts an influence on the fatty acid composition of cholesterol ester of the rat adrenal glands and it also improves the fatty acid compsition of serum cholesterolester of hypercholesteremic rats.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-03-25
54巻
開始ページ 19
終了ページ 24
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310999
JaLCDOI 10.18926/21103
タイトル(別表記) Effects of swimming training in the hot spring pool on ventilatory function in bronchial asthma
フルテキストURL pitsr_054_013_018.pdf
著者 周藤 真康| 駒越 春樹| 岡田 千春| 中郷 実雄| 谷崎 勝朗| 森永 寛|
抄録 Effect of free swimming training in the hot spring pool (30℃) on ventilatory function were observed in nine patients with intractable asthma by measuring FVC, FEV(1.0), PEFR, MMF, V(50), V(25). 1. Swimming in the hot spring pool for three months allowed the reduction of glucocorticoid used for their asthma attack. 2. Although FVC was not affected by swimming training, EEV(1.0), PEFR, MMF, V(50), V(25) which represent obstructive ventilatory function were gradually improved by swimming training. The results show that free swimming training in the hot springpool is clinically available in intractable asthma.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-03-25
54巻
開始ページ 13
終了ページ 18
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310964
JaLCDOI 10.18926/21106
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 3. 抗ヒトIgE に対する好塩基球の反応性と末梢血好酸球増多
フルテキストURL pitsr_054_035_038.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 御般 政明| 森永 寛| 中川 三郎| 貴谷 光| 木村 郁郎|
抄録 Histamine release from basophils induced by anti-IgE was examined in 14 asthmatic subjects with blood eosinophilia. The subjects were divided into two groups; group I (with blood eosinophilia, positive skin test and positive RAST to house dust) and group II (with blood eosinophilia, negative skin test to various allergens and negative RAST to house dust). 1. Serum IgE levels in group I were much higher than those in group II. 2. Maximum percent histamine release induced by anti-IgE was much higher in group I than in group II. 3. Dose-response curve of anti-IgE-induced histamine release in group I showed consistent increase as anti-IgE concentrations increased. while, dose-response curve in group II was very low. These findings suggested that blood eosinophilia in group I might be elicited relating to IgE-mediated reaction. However, mechanism causing eosinophilia in group II was not clear in the present study.
抄録(別表記) 末梢血好酸球増多を示す気管支喘息14症例について,抗ヒトIgE による好塩基球からのヒスタミン遊離を検討した. ハウスダストに対する皮内反応およびRASTが陽性を示す症例群(groupI)では,血清IgE値が高く,また抗ヒトIgEによるMax. % ヒスタミン遊離も高く(50.7士5.0%),そのdoseresponse curveは抗ヒトIgE添加濃度が高くなるにつれて上昇する傾向を示した.一方種々のアレルゲンエキスに対する皮内反応が陰性で,かつRAST も陰性を示す症例群(group II)では,血清IgE値が低く,また抗ヒトIgEによるMax. % ヒスタミン遊離も低く(10.5士1.7%),そのdose-response curveは全般的に低く,抗ヒトIgE添加濃度が高いところではむしろ抑制される傾向を示した.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-03-25
54巻
開始ページ 35
終了ページ 38
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310989
JaLCDOI 10.18926/21120
タイトル(別表記) Clinical effects of swimming training in a hot spring pool on bronchial asthma
フルテキストURL 053_035_043.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 村嶋 誠| 岡田 千春| 森永 寛| 小橋 秀敏| 多田 慎也| 木村 郁郎|
抄録 Five severe bronchial asthma patients with glucocorticoid therapy have had free swimming training in the hot spring pool at Misasa Medical Branch. The clinical effect of the swimming training was evaluated after 3 months' training. 1. A slight increase in pulse rate and blood pressure was observed immediately after 30 minutes, swimming, although no significant increase in the two parameters was shown 30 min. after the training. 2. No significant fall in ventilatory function tests such as % FVC, FEV(1.0)%, V(50) and V(25) was demonstrated following the swimming training in a hot spring pool. The results suggest that the free swimming training in a hot spring pool does not induce bronchoconstriction. 3. Clinical efficacy of the swimming training on bronchial asthma was evaluated according to a treatment score, an attack score and an asthmatic score. These scores were decreased during the swimming training. The results obtained in this study showed that free swimming training in a hot spring pool is one of the most suitable therapies for severe bronchial asthma patients.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 35
終了ページ 43
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 40000321171
JaLCDOI 10.18926/21118
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 1 自動分析装置による全血からのヒスタミン遊離の測定
フルテキストURL pitsr_053_023_028.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 御般 政明| 森永 寛| 大谷 純| 貴谷 光| 合田 吉徳| 多田 慎也| 木村 郁郎|
抄録 Histamine released from whole blood was determined by an automated fiuorometric histamine analysis system. The increased release of histamine from basophils by anti-IgE was observed in ten healthy subjects and 12 extrinsic asthma patients, while the release in 11 intrinsic asthma patients was significantly less as compared to that in healthy and extrinsic asthma subjects. House dust extract caused a significant increase in the histamine release from basophils of the extrinsic asthma patients who are sensitive to house dust. It was concluded from this study that histamine released from basophils could be easily determined by an automated analysis system and that the method is useful for the diagnosis and study of allergy.
抄録(別表記) ヒスタミン自動分析装置により,健康人10名,気管支喘息23例の全血からのヒスタミン遊離を測定した. 抗ヒトIgEを添加した際のヒスタミン遊離は,健康人および外因性気管支喘息症例では有意の増加傾向を示したが,一方内因性喘息症例では遊離増加はほとんどみられなかった. ハウスダスト抗原添加では,ハウスダストが抗原である気管支喘息症例においてのみ全血からの有意のヒスタミン遊離の増加が観察された. 以上の結果より,ヒスタミン自動分析装置による全血からの遊離ヒスタミンの測定は,気管支喘息の病態解明の1手段として極めて有用であると考えられる.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 23
終了ページ 28
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310945
JaLCDOI 10.18926/21115
タイトル(別表記) Hypnotic effect of the peloid therapy applied on the right hypochondrium in reference to plasma L-tryptophan
フルテキストURL pitsr_053_009_011.pdf
著者 森永 寛| 古元 順子| 古元 嘉昭|
抄録 Based on the EEG-observation of falling asleep when patients are under peloid therapy applied on the right hypochondrium, following assumption is made to clarify the mechanism of inducing sleep. While patients are under the peloid therapy, some chemical substance will be produced in circulating blood; L-tryptophan, an essential amino acid and a precursor of serotonin, gets over a blood-brain barrier easily to induce sleep. Six healthy volunteers, each sex by threes, were selected to apply peloid pack on the right hypochondrium for 30 minutes following 12-hour fasting. Significant increase in plasma L-tryptophan level was obtained in the clinical experiment. It is speculated from the preliminary data that L-tryptophan increased by the peloid therapy may possibly act as a specific physiological hypnotics.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 9
終了ページ 11
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311031
JaLCDOI 10.18926/21114
タイトル(別表記) Determination of ferritin in serum and in synovial fluids of patients with rheumatoid arthritis
フルテキストURL pitsr_053_001_008.pdf
著者 古野 勝志| 森永 寛| 入野 昭三|
抄録 Ferritin in sera and in synovial fluids were determined by method of immunoradiometric assay (IRMA) and of radioimmunoassay (RIA). These methods have been proved to be reproducible. The coefficient variation was 7.4 to 9.9% in IRMA and 5.6 to 8.0% in RIA. There were a good correlation between methods of IRMA and of RIA (r=0.989). The mean recovery rate of ferritin in serum was 101.2% in IRMA and 101.0% in RIA, respectively. The determination of serum ferritin revealed a 16% reduction in average after preservation at -20℃ during over 100 days. The levels of serum ferritin in healthy controls were 131.4±52.1 ng/ml in 34 males and 58.4±39.9 ng/ml in 38 females. The sex differences were statisticalIy significant (p<0.01). Ferritin levels were shown to be below 30 ng/ml (the state of iron deficiency) in 2 of 34 (5.9%) males and in 8 of 38 (21%) females of healthy controls. The levels of serum ferritin in patients with rheumatoid arthritis (RA) were 337.0±293.4ng/ml in 10 males and 181.4±329.9ng/ml in 25 females. The serum ferritin in RA was significantly higher than in healthy controls of both sexes. The levels of ferritin in synovial fluids of patients with 14 RA and with 12 osteoarthritis were 2894±3017 ng/ml and 1429±1005 ng/ml, and no differences were observed in both groups.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 1
終了ページ 8
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311016