著者 井上 妙子| 池上 忠興| 森永 寛|
発行日 1970-03-30
出版物タイトル 岡山大学温泉研究所報告
39巻
資料タイプ データ・データベース
JaLCDOI 10.18926/21170
タイトル(別表記) General survey of the spa treatment at Misasa Spa (2nd report)
フルテキストURL pitsr_049_015_019.pdf
著者 森永 寛|
抄録 A general survey of the spa treatment at Misasa Spa carried out in February, 1979. The informations the author has gathered may be summarized as follows: 1. The majority of spa visitors was over 60 years old. 2. 47% of spa visitors came to this hot spring for rest and recreation, 43% for the purpose of balneotherapy of chronic rheumatic disorders and after-care. 3. Those who visited Misasa Spa for the first time were 32%, the rest being those who visited this spa over 2 times. 4. The length of time they stay at Misasa Spa for recreation was under 7 days, and for curative treatment was for about 2 weeks.
出版物タイトル 岡山大学温泉研究所報告
発行日 1979-09-25
49巻
開始ページ 15
終了ページ 19
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310935
JaLCDOI 10.18926/40322
タイトル(別表記) THE CLINICAL STUDIES OF RHEUMATOID ARTHRITIS (I)
フルテキストURL 016_035_048.pdf
著者 森永 寛|
抄録 The value of spa treatment of rheumatic disease is an established feature of medical management based on experiences for many centuries. The author has been practising the balneotherapy of rheumatic diseases at Misasa Spa for several years, and has found this therapy efficacious in many cases in relieving the anemia that accompanies rheumatoid arthritis. For this reason, the author is investigating the metabolism of iron in rheumatic anemia, which is expected to occur in the course of the spa treatment. In this report, the results of clinical examinations of 24 patients with rheumatoid arthritis, of the type (2. 2. 2.) Polyarthritis systemica chronica (in Prof. Kodama's classification of arthritis), are described. I. Some observations of anemia in rheumatoid arthritis 1. The peripheral blood The number of erythrocytes is 266×10(4)~455×10(4)/c. mm. (average: (381±32)×10(4)/c. mm.), Hb-content : 55~90% (average : 76±5.8%), and the color index is about 1.0. The anemia of rheumatic disease treated is mostly normochromic. The white blood count is between 3240 and 13300/c. mm. (average: 6421±955/c. mm. ), and the number of the leucocytes in 80% of the cases ranges within the normal limits. Eosinophilia is observed in 15% of the cases. 2. Anemia-producing substance in the serum of rheumatoid arthritis When serum from rheumatoid arthritis patients was injected into rabbits, the number of erythrocytes and the hemoglobin -content of the rabbits was found to decrease markedly for 2~6hours after the injection. But no such effect was observed when the serum of healthy subjects was injected. From this, the author presumes the presence of an anemia-producing substance in the serum of rheumatoid arthritis. The nature of this substance in now under investigation. II. Clinical-biochemical studies 3. Gastric acidity of rheumatic patients Of 7 cases examined, anacidity of gastric juice was observed in 2 cases, subacidity in other 2 cases and normacidity in the remaining 3 cases. Thus, a decrease in the gastric acidity was found to occur in 57% of the cases. 4. Takata-serum-test and sedimentation rate It is said that the sedimentation rate and the Weltmann-reaction are very sensitive indicators of the extent of the activity of rheumatic disease. The Takata-serum-test was applied in 18 cases and was found to give positive results in 10 cases (55%). The sedimentation rate was found to increase in 17 of 20 cases (85%). 5. Blood uric acid As is well known, the concentration of uric acid is abnormally high in the blood of patients with gout; while, according to the literature, the blood uric acid levels of patients with rheumatoid arthritis range within the normal limits. The author, using the method of Benedict, obtained the following results for blood uric acid in 14 normal subjects in fasting state: Range - 2.30~3.47mg./dl. , 5% rejection limit -- 1.97~3.68mg./dl. In 5 of 7 cases of rheumatoid arthritis, the blood uric acid levels were shown to be above the upper limit of the normal range, but the concentrations of blood uric acid of non-rheumatic joint diseases and neuralgias were mostly within the normal range. 6. Blood sugar The fasting blood sugar levels of rheumatoid patients ranged from 82 to 1l0mg./dl. (average : 100mg./dl.), higher than the levels of healthy subjects (78~108mg./dl., average : 90mg./dl.). The intravenously injected glucose load test was applied to 8 rheumatoid patients. A solution of 40 ml. of 20% glucose was injected into a fasting subject for 2 minutes. Blood samples were taken before the injection, 3 minutes after the injection, and at each subsequent 10 minute-interval for 70 minutes. The glucose tolerance curves in 5 of these cases were found to be out of the normal range. It is to be noticed that the average blood sugar for rheumatoid arthritis is similar to the curve for liver disease. 7. Serum alkaline phosphatase activity and serum phosphorus The method of Taussky-Shorr was used for the determination of the level of alkaline phosphatase activity and inorganic phosphate in the serum. The alkaline phosphatase activity of 11 normal individuals ranged from 1.4 to 6.4 Shinowara-Jones-Rheinhart units/dl. (5% rejection limit), while in 4 of 8 cases of rheumatoid arthritis, it was of abnormally high levels. The concentration of inorganic phosphate in the serum of 12 normal subjects ranged from 2.9 to 5.0mg. /dl. (5% rejection limit), while in 3 cases of rheumatoid patients, it showed higher levels than normal. 8. Total cholesterol in serum The total cholesterol in the serum of fasting normal individuals was measured by Bloor's method, and the concentration was found to range from 124 to 188mg./dl. (rejection limit of 5% level of significance), and the total cholesterol in the serum of rheumatoid arthritis to be abnormally high in concentration in 6 of 7 cases. The liver function was evaluated by the Takata-serum-test, the test of fasting blood sugar levels, the glucose load test, and the test of serum alkaline phosphatase activity; and from this the hepatic dysfunction was found to occur in rheumatoid arthritis patients in about 50% of the cases examined. Disturbances in the protein, fat, and carbohydrate metabolism were also found to occur. The above-mentioned findings indicate that rheumatoid arthritis is not only a disease of the joints, but also a general and systemic illness. Attention must accordingly be given to the general condition of the patient in the treatment of rheumatic disease.
出版物タイトル 岡山大学温泉研究所報告
発行日 1956-01
16巻
開始ページ 35
終了ページ 48
ISSN 0369-7142
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/40318
言語 Japanese
論文のバージョン publisher
NAID 40017532470
JaLCDOI 10.18926/21086
タイトル(別表記) Effect of serial bathing on circadian variation of plasma metabolites in rats
フルテキストURL pitsr_056_035_043.pdf
著者 妹尾 敏伸| 原田 英雄| 御船 政明| 森永 寛|
抄録 The effect of serial bathing (10-minute bathing in city water or Misasa hot spring, 40℃, once daily for one or four weeks) on the circadian variations of plasma metabolites was studied in three groups of rats : hot spring bathing rats, city water bathing rats and non-treated rats. Plasma obtained by decapitation at 8:00, 12:00, 16:00, 20:00 and 24:00 hours was analysed for catecholamines (CA), free fatty acids (FFA), cholesterol (C) and glucose. 1) Noradrenaline (NA) and adrenaline (A) were significantly lower at 24:00 hours with significantly lower 24-hour average concentrations and also with significantly different diurnal patterns in the 1-week hot spring bathing rats; in the 4-week hot spring bathing rats, lower 24-hour average concentrarion of A was the only significant finding. The results suggest the suppressive effect of hot spring bathing on the sympathetic system or pituitary gland-adrenal medulla; they also suggest the adaptation to hot spring bathing. 2) Free fatty acids were significantly higher in the 1-week hot spring bathing rats at 12:00 hours as compared with non-treated rats and city water bathing rats. The 4-week hot spring bathing rats showed concentration of FFA not different from the remaining two groups of rats. No significant difference was noted in diurnal patterns among the three groups of rats. The results suggest that the high FFA concentrations in the 1-week hot spring bathing rats are related to the physico-chemical constituents of the hot spring to some extent and that the rats adapt themselves to bathing during the 4-week preriod. 3) Cholesterol was significantly lower in the 4-week hot spring bathing rats as compared with non-treated rats and city water bathing rats; no different diurnal patterns were noted among the three groups of rats. The results suggest the suppressive effect of 4-week hot spring bathing on plasma cholesterol concentrations as reported previously by us. 4) No Significant difference was noted in concentrations as well as in diurnal patterns of plasma glucose among the three groups of rats. The results suggest that bathing has no significan effect on concentrations and diurnal patterns of plasma glucose in healthy rats.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 35
終了ページ 43
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310969
JaLCDOI 10.18926/21135
タイトル(別表記) Studies on Rat Peritoneal Mast Cells 2. Effect of BSA on Ca(2+) Uptake of Mast Cells
フルテキストURL pitsr_052_029_032.pdf
著者 谷崎 勝朗| 田中 淳太郎| 駒越 春樹| 森永 寛| 岸本 卓巳| 木村 郁郎| Townley Robert G.|
抄録 To examine the effect of BSA on the cell surface of mast cells, the (45)Ca influx was observed in mast cells from actively sensitized rats and also in cells passively sensitized with IgE-containing serum before or after purification by BSA. The mast cells from actively sensitized rats showed a marked increase in the (45)Ca uptake with stimulation by ovalbumin. The value of (45)Ca uptake by the cells was 1495 ± 104 cpm / 10(5) cells. The uptake of (45)Ca by mast cells passively sensitized before or after separation through BSA was also increased in response to ovalbumin, although the degree of 45Ca uptake by the latter showed marked variation. These results may suggest that BSA affects mast cell surface when the cells are sensitized after separation by BSA.
出版物タイトル 岡山大学温泉研究所報告
発行日 1982-03-25
52巻
開始ページ 29
終了ページ 32
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311041
JaLCDOI 10.18926/21134
タイトル(別表記) Studies on Rat Peritoneal Mast Cells 1. Purification of Mast Cells From Rat Peritoneal Cavity
フルテキストURL pitsr_052_023_028.pdf
著者 谷崎 勝朗| 田中 淳太郎| 駒越 春樹| 森永 寛| 岸本 卓巳| 木村 郁郎| Townley Robert G.|
抄録 To get a high recovery rate of mast cells from the rat peritoneal cavity, a new modified method was discussed using BSA density gradient. Three procedures, peritoneal lavage, washing of peritoneal cells and purification by BSA, were tested in this study, and the numbers of total cells and mast cells in each procedure were calculated. The recovery rate was the highest in BSA density gradient purification of the cells washed once with low speed centrifugation. The recovery rate was 73.7% and the number of mast cells taken from one rat was approximately 1.5×10(6). The purity of the cells with this procedure was 95.0% (range from 93.0 to 96.0%).
出版物タイトル 岡山大学温泉研究所報告
発行日 1982-03-25
52巻
開始ページ 23
終了ページ 28
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310940
JaLCDOI 10.18926/21104
タイトル(別表記) Effects of serial bathing on fatty acid composition of adrenal and serum cholesterol ester in rats
フルテキストURL pitsr_054_019_024.pdf
著者 妹尾 敏伸| 原田 英雄| 御船 政明| 森永 寛|
抄録 The effects of serial bathing (10 minutes bathing in a city water or hot spring in Misasa, 40℃, once daily for 1-4 weeks) on fatty acid composition of cholesterol ester of the adrenal glands and serum was studied in both normal and hypercholesteremic rats. Although the adrenal cholesterol ester levels were relatively unaffected in rats treated with serial bathing as well as non-treated rats, the proportion of 18 : 2 was increased in rats treated with hot spring bathing for 3-4 weeks. The serum cholesterol ester levels in both normal and hypercholesteremic rats tended to decrease after serial bathing for 3-4 weeks compared with non-treated rats. The fatty acid composition of serum cholesterol ester in normal rats was unaffected. The composition in hypercholesteremic rats showed an increase in the proportion of 16 : 1 and 18 : 1 and a decrease of 18 : 2 and 20: 4 compared with normal rats. When those of hypercholesteremic rats were treated with serial bathing for 3 weeks, particularly with hot spring bathing, the proportion of 16 : 1, 18: 2 and 20 : 4 showed a tendency to approach that in tormal rats. The findings indicate that serial hot spring bathing for 3-4 weeks, unlike city water bathing, exerts an influence on the fatty acid composition of cholesterol ester of the rat adrenal glands and it also improves the fatty acid compsition of serum cholesterolester of hypercholesteremic rats.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-03-25
54巻
開始ページ 19
終了ページ 24
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002310999
JaLCDOI 10.18926/21180
タイトル(別表記) Determination of boron in thermal waters by emission spectrophotometry using "Spectraspan"
フルテキストURL pitsr_048_035_041.pdf
著者 御船 政明| 青木 宏子| 鉄本 潤子| 古野 勝志| 森永 寛|
抄録 A plasma emission spectrophotometer "Spectraspan" (low power d. c. plasma arc, operating on argon) was evaluated for boron determination in thermal waters. The influence of acids (hydrochloric, nitric and sulfuric acids) and several metallic ions (Na(+). K(+), Mg(2+). Ca(2+)) on emission intensity was studied. There was a linear relationship between emission intensity and boron content from 0 to 500 mg/l. Boron in thermal waters was easily determined by standard addition method. Precision. coefficient of variance and recoveries of known amount of boron added to the sample for 11 repricate analyses were 0.12μg/ml, 2.02%, 95.0-101.7%, respectively. Boron content of 27 thermal waters in the Sanin district was determined. and the highest B content in the sample waters were 8.8 mg/l (Tottori spa) in Tottori Prefecture and 14.6-25.0 mg/l (the thermal springs at the foot of Mt. Sanbe. a non-active quaternary volcano) in Shimane Prefecture. The relationships between B content and water temperature, B content and pH value were not recognized. Significantly positive correlationship was observed between Band Li contents.
出版物タイトル 岡山大学温泉研究所報告
発行日 1979-03-25
48巻
開始ページ 35
終了ページ 41
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 120002311017
JaLCDOI 10.18926/19683
タイトル(別表記) Studies on anti-allergic actions of tranilast (Rizaben®)
フルテキストURL 057_042_045.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 森永 寛| 大谷 純| 木村 郁郎|
抄録 抗アレルギー剤(脱顆粒抑制剤)の1つであるtranilastの肥満細胞の遊離機序に対する抑制作用について検討を加えた。1.抗原刺激時の肥満細胞の(45)Ca uptakeおよびヒスタミン遊離に対して,tranilastは有意の抑制作用を示したが,comp.48/80刺激時にはtranilastの(45)Ca uptake,ヒスタミン遊離に対する抑制作用はほとんどみられなかった。2.phosphatidylserine添加時には,(45)Ca uptakeに対するtranilastの抑制作用は減弱傾向を示し,この傾向はヒスタミン遊離に対する作用に比べより高度であった。3.抗原および抗ヒトIgEによる好塩基球からのヒスタミン遊離に対して,tranilastは明らかな抑制作用を示さなかった。
抄録(別表記) Tlanilast is clinically used for bronchial asthma as one of the prophylactic agents for asthma attacks. In this study, anti-allergic actions of tranilast were examined in (45)Ca uptake of and histamine release from target cells of IgE after stimulation with antigen, anti-IgE and camp. 48/80. 1. (45)Ca uptake of and histamine release from rat peritoneal mast cells stimulated by antigen were significantly inhibited by preincubation of the cells with tranilast. Inhibition by tranilast of increased (45)Ca uptake of mast cells by addition of phosphatidylserine were less, although inhibition of histamine release was not so affected by addition of phosphatidylserine. No significant inhibition by tranilast of (45)Ca uptake and histamine release was not observed when the cells were stimulated by camp. 48/80. 2. Tranilast showed any inhibitory effects on basophil histamine release induced by antigen and anti-IgE.
キーワード トラニラスト (tranilast) (45)Ca取り込み ((45)Ca uptake) ヒスタミン遊離 (histamine release) 肥満細胞 (mast cell) 好塩基球 (basophils)
出版物タイトル 環境病態研報告
発行日 1986-07
57巻
開始ページ 42
終了ページ 45
ISSN 09133771
言語 Japanese
論文のバージョン publisher
NAID 120002308998
JaLCDOI 10.18926/21083
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 5.臨床的評価
フルテキストURL pitsr_056_017_021.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 森永 寛|
抄録 過去3年間にわたり,気管支喘息患者末梢血好塩基球からのヒスタミン遊離について,ヒスタミン自動分析装置を用いて全血法により検討を加えてきた. 1. 抗ヒトIgE によるヒスタミン遊離は,症例間で著しい差がみられた. この際血清IgE値が高値を示す症例では全般的に高度なヒスタシソ遊離がみられたが,血清IgE値が正常かまたはむしろ低値を示す症例のヒスタミン遊離は,かなり高度なものから全くみられないものまでさまざまであった. 2.ハウスダストやカンジダなどの抗原物質によるヒスタミン遊離は,特異的IgE抗体依存性であり,抗体価が上昇するにつれヒスタミン遊離は高度となる傾向がみられた. しかし,ハウスダストとカンジダによるヒスタミン遊離には若干の差がみられた. すなわち,ハウスダストと抗ヒトIgE によるヒスタミン遊離の間には密接な関連がみられたが,カンジダと抗ヒトIgEの間には全く関連がみられなかった. またカンジダによるヒスタミン遊離においては,IgE系反応以外の反応が関与する可能性が一部示唆された.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 17
終了ページ 21
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310985
JaLCDOI 10.18926/21095
タイトル(別表記) Spa therapy for patients with chronic obstructive lung disease
フルテキストURL pitsr_055_007_010.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 森永 寛| 貴谷 光| 中川 三郎| 木村 郁郎|
抄録 Histamine releasse from basophils induced by house dust and C. albicans was examined in 30 patients with bronchial asthma. House dust and C. albicans caused a significant amount of histamine release in subjects with a RAST score to corresponding allergen. A close correlation was found between house dust- and anti-IgE-induced histamine release. However, histamine release induced by C. albicans was considerably different from the release induced by anti-IgE.
抄録(別表記) ハウスダストあるいはカンジダが特異抗原である気管支喘息30例を対象に,それぞれの抗原刺激時の好塩基球からのヒスタミン遊離を,抗ヒトIgEによる遊離と比較検討した. 1. ハウスダストが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時41.8%,抗ヒトIgE刺激時40.8%であった. 2. カンジダが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時27.1%,抗ヒトIgE刺激時32.2%であった. 3. ハウスダストと抗ヒトIgEによる好塩基球からのヒスタミン遊離は,ほぼ同様の値を示した. 一方カンジダと抗ヒトIgEによるヒスタミン遊離の間には有意の 相関関係はみられなかった.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-11-30
55巻
開始ページ 7
終了ページ 10
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310939
JaLCDOI 10.18926/21106
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 3. 抗ヒトIgE に対する好塩基球の反応性と末梢血好酸球増多
フルテキストURL pitsr_054_035_038.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 御般 政明| 森永 寛| 中川 三郎| 貴谷 光| 木村 郁郎|
抄録 Histamine release from basophils induced by anti-IgE was examined in 14 asthmatic subjects with blood eosinophilia. The subjects were divided into two groups; group I (with blood eosinophilia, positive skin test and positive RAST to house dust) and group II (with blood eosinophilia, negative skin test to various allergens and negative RAST to house dust). 1. Serum IgE levels in group I were much higher than those in group II. 2. Maximum percent histamine release induced by anti-IgE was much higher in group I than in group II. 3. Dose-response curve of anti-IgE-induced histamine release in group I showed consistent increase as anti-IgE concentrations increased. while, dose-response curve in group II was very low. These findings suggested that blood eosinophilia in group I might be elicited relating to IgE-mediated reaction. However, mechanism causing eosinophilia in group II was not clear in the present study.
抄録(別表記) 末梢血好酸球増多を示す気管支喘息14症例について,抗ヒトIgE による好塩基球からのヒスタミン遊離を検討した. ハウスダストに対する皮内反応およびRASTが陽性を示す症例群(groupI)では,血清IgE値が高く,また抗ヒトIgEによるMax. % ヒスタミン遊離も高く(50.7士5.0%),そのdoseresponse curveは抗ヒトIgE添加濃度が高くなるにつれて上昇する傾向を示した.一方種々のアレルゲンエキスに対する皮内反応が陰性で,かつRAST も陰性を示す症例群(group II)では,血清IgE値が低く,また抗ヒトIgEによるMax. % ヒスタミン遊離も低く(10.5士1.7%),そのdose-response curveは全般的に低く,抗ヒトIgE添加濃度が高いところではむしろ抑制される傾向を示した.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-03-25
54巻
開始ページ 35
終了ページ 38
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310989
JaLCDOI 10.18926/21118
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 1 自動分析装置による全血からのヒスタミン遊離の測定
フルテキストURL pitsr_053_023_028.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 御般 政明| 森永 寛| 大谷 純| 貴谷 光| 合田 吉徳| 多田 慎也| 木村 郁郎|
抄録 Histamine released from whole blood was determined by an automated fiuorometric histamine analysis system. The increased release of histamine from basophils by anti-IgE was observed in ten healthy subjects and 12 extrinsic asthma patients, while the release in 11 intrinsic asthma patients was significantly less as compared to that in healthy and extrinsic asthma subjects. House dust extract caused a significant increase in the histamine release from basophils of the extrinsic asthma patients who are sensitive to house dust. It was concluded from this study that histamine released from basophils could be easily determined by an automated analysis system and that the method is useful for the diagnosis and study of allergy.
抄録(別表記) ヒスタミン自動分析装置により,健康人10名,気管支喘息23例の全血からのヒスタミン遊離を測定した. 抗ヒトIgEを添加した際のヒスタミン遊離は,健康人および外因性気管支喘息症例では有意の増加傾向を示したが,一方内因性喘息症例では遊離増加はほとんどみられなかった. ハウスダスト抗原添加では,ハウスダストが抗原である気管支喘息症例においてのみ全血からの有意のヒスタミン遊離の増加が観察された. 以上の結果より,ヒスタミン自動分析装置による全血からの遊離ヒスタミンの測定は,気管支喘息の病態解明の1手段として極めて有用であると考えられる.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 23
終了ページ 28
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310945
JaLCDOI 10.18926/21119
タイトル(別表記) 好塩基球からのヒスタミン遊離に関する研究. 2. ハウスダスト抗原および抗ヒトIgEによるヒスタミン遊離
フルテキストURL pitsr_053_029_033.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 御般 政明| 森永 寛| 貴谷 光| 合田 吉徳| 多田 慎也| 木村 郁郎|
抄録 IgE-mediated release of histamine from whole blood was examined in two healthy and four asthmatic subjects by dose-dependent fashion. The significantly increased amount of histamine was released from basophils of both healthy and asthmatic subjects by a limited concentration of anti-IgE. Antigen (house dust) caused histamine release only from basophils of asthmatics who are sensitive to house dust. Basophils from one patients with asthma released no significant amount of histamine by anti-IgE.
抄録(別表記) 好塩基球からのIgE-mediated histamine releaseの機序を,健康人(2名)および気管支喘息(4例)それぞれの代表例で比較検討した. 抗ヒトIgEの添加濃度別検討では,健康人および外因性喘息例いずれも有意のヒスタミン遊離の増加をしめしたが,Max. % histamine releaseをひきおこす抗ヒトIgEの濃度は比較的限られた範囲内にある傾向がみられた. 一方内因性喘息例では,いずれの抗ヒトIgE濃度でも有意のヒスタミン遊離はみられなかった. ハウスダスト抗原の添加濃度別検討では,ハウスダストが抗原である気管支喘息症例においてdose-dependentなヒスタミン遊離が観察されたが,使用された抗原濃度の範囲ではMax. % releaseをひきおこす至適濃度は明らかでなかった.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 29
終了ページ 33
ISSN 0369-7142
言語 English
論文のバージョン publisher
NAID 120002310980
JaLCDOI 10.18926/40077
タイトル(別表記) A FORTRAN data processing system for the epidemiological data on rheumatic diseases - Part 1. Basic programs for deposit and retrieval of data
フルテキストURL 046_045_059.pdf
著者 伊東 恵子| 北山 稔| 森永 寛| 松井 義人|
抄録 A set of FORTRAN programs for small computer is described for deposit and retrieval of the epidemiological data, which have been compiled at the Kami-hojo-cho district in Feb. 1972and Feb. 1975. A data file is constructed on a magnetic disk. The following items are recorded and registered on the disk for every person: identification number, full name in Japanese alphabet, sex, date of birth, weight, height, blood pressures, chemical characterics of blood serum and urine, and various complaints of clinical significance (fever, morning stiffness, arthralgia, joint swelling, myalgia, cutaneous rash, aphthous stomatitis, dry eyes, dry mouth, joint deformity, subcutaneous nodules, lymph and parotid gland enlargement, struma, heart murmur, and neulogical findings). All information per one person requires only two IBM cards due to compact encoding of original records. The encode-decode procedures are explained also in the text.
出版物タイトル 岡山大学温泉研究所報告
発行日 1977-03-25
46巻
開始ページ 45
終了ページ 59
ISSN 0369-7142
言語 Japanese
論文のバージョン publisher
NAID 40000321122