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ID 16000
Eprint ID
16000
フルテキストURL
Thumnail 100_793.pdf 2.18 MB
タイトル(別表記)
Effect of immersion stress on guanidino compounds in rat organs.
著者
杉 英樹 岡山大学医学部脳代謝研究施設機能生化学部門
抄録
The effect of immersion stress on guanidino compounds in rat organs was studied. Short-term (5min) immersion stress increased the creatinine level in the cerebral cortex and the homoarginine level in the cerebellum, but it did not affect guanidino compound levels in the liver, kidney and pancreas. On the other hand, long-term (60min) immersion stress decreased the creatinine level in the liver and the arginine level in the kidney, and increased the arginine and γ-guanidinobutyric acid levels in the liver. However, long-term immersion stress did not affect guanidino compound levels in the brain or pancreas. Further, long-term immersion stress increased the excretion of γ-guanidinobutyric acid in the urine. These findings suggest that the transient increases of creatinine in the cerebral cortex and homoarginine in the cerebellum might be related to a functional change in the central nervous system during the early stage of immersion stress. It is thought that the long-term immersion stress affects guanidino compound metabolism in the peripheral organs through changes in protein metabolism.Administration of imipramine reduced the lowered mood induced in rats by immersion stress, but it did not affect the change in guanidino compound levels induced by long-term immersion stress. This result suggests that the alleviation of the lowered mood induced in rats by imipramine treatment is not related to changes in guanidino compound levels in rat organs.
キーワード
水浸ストレス
ラット
グアニジノ化合物
肝臓
腎臓
塩酸imipramine
発行日
1988
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
100巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
793
終了ページ
802
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/100/7-8/100_7-8_793/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma