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ID 17670
Eprint ID
17670
フルテキストURL
Thumnail 88_889.pdf 6.05 MB
タイトル(別表記)
A histochemical study on hypertensive intracerebral hemorrhage
著者
本条 征史 岡山大学医学部脳神経外科教室
抄録
Histochemical studies have been carried out to evaluate the effect of evacuation of hematoma in the case of the hypertensive intracerebral hemorrhage and also the effect of oral administration of pyridinol-carbamate in such surgical procedure. Experimental renal hypertension of 34 male rabbits was made by Goldblatt's method, 12 rabbits were dead for hypertensive condition, including a rabbit with massive intracerebral hemorrhage. Normal 4 rabbits were used as control group. Artificial intracerebral hematoma was made in 18 hypertensive rabbits by injection of 0.3ml of venous auto-blood into the area of the internal capsule through a small burr hole stereotaxically. The hematoma were evacuated by insertion of 18 gauge needle 3 days after the blood injection. The results were as follows: a) Rabbits of experimental hypertensive intracerebral hematoma were divided into two groups; 5 rabbits medicated with pyridinol-carbamate of 30mg/kg B.W. for about 9 weeks preoperatively and 4 non-medicated rabbits. In the non-medicated group, enzymatic activities of LDH of Embden-Meyerhof pathway, SDH and MDH of TCA cycle, Cy-O of the electron transport system and also Al-p, Ac-p of the hydrolytic enzymes were diminished in the adjacent area of the hematoma. This indicated the considerable decrement for maintenance of metabolism, tissue respiration and the cell function in that area. In contrast, G-6-PDH of Warburg-Dickens pathway was accelerated in the cortex. It suggested that hexose-monophosphate shunt was playing an important role of metabolism in this pathological conditions. These enzymatic activities of medicated group showed also similar pattern to that of nonmedicated group. They showed, however, rather minimum changes. b) In 9 rabbits with hypertensive intracerebral hematoma, the hematoma were evacuated afterwards. These rabbits were also divided into two groups; 5 medicated with pyridinolcarbamate and 4 non-medicated rabbits. In the non-medicated group, LDH, SDH, MDH activities as well as Ac-p and Al-p activities were decreased in the adjacent cerebral tissue of the evacuated hematoma. However, Cy-O activity showed almost normal. This indicated that extirpation of the blood-clot was effective for the restoration of the destructed blood brain barrier and the disturbed metabolism in the cerebral tissue. In the medicated group, these all enzymatic activities showed almost normal in that area. These results suggest for us that the surgical evacuation of intracerebral hematoma is a choice of treatment and that the preventive medical treatment such as oral administration of pyridinol-carbamate should be combined with the surgical management under these hypertensive condition.
発行日
1976-10-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
88巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
889
終了ページ
911
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/88/9-10/88_9-10_889/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma