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ID 14239
Eprint ID
14239
フルテキストURL
Thumnail 104_145.pdf 301 KB
タイトル(別表記)
Measurement of Danazol and its metabolites by automated direct assay system
著者
木山 智之 岡山大学医学部産科婦人科学教室
抄録
An automated direct assay system using high performance liquid chromatography was developed for teh measurement of Danazol ; DA and its two metabolites, △(1)-2-hydroxymethylethisterone (△(1)-2-HME), and 2-hydroxymethylethisterone (2-HME), in biologi-cal fluid (human serum and ascites). Serum concentrations of these compounds were measured up to 24 h following a single oral administration of 200mg of DA to 6 females with en-dometriosis. The maximum serum concentration of DA, △(1)-2-HME and 2-HME was 208, 44 and 58ng/ml, respectively. The serum half-life of DA, △(1)-2-HME and 2-HME was 7.9, 4.3 and 4.4 h, respectively. The mean serum concentration of DA and its two metabolites at the the sampling time (2 h after oral administration of 200mg of DA every 4 weeks) hardly changed in the patients administered 400mg/day of DA over a period of 16 weeks. DA and △(1)-2-HME were detectable in ascites 2, 4 and 8 h after oral administration of 200mg of DA, and 2-HME was detectable in ascites at 4 and 8 h. This system could quantify DA and its matabolites easily and simultaneously, and was considered to be valuable in the studies on the relationship between the pharmaco-kinetics and the clinical effects of DA.
キーワード
高速液体クロマトグラフィー
ダナゾール
ダナゾール代謝産物
発行日
1992
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
104巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
145
終了ページ
150
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
http://www.journalarchive.jst.go.jp/japanese/jnlabstract_ja.php?cdjournal=joma1947&cdvol=104&noissue=1-2&startpage=145
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma