Sort Key 6
タイトル(別表記) Metastatic breast cancer presenting as severe anemia, platelet reduction and abnormal cells in peripheral blood
フルテキストURL 126_31.pdf
著者 太田 誠介| 笠原 明宣| 水野 翔馬| 深津 遥香| 木下 修| 野口 敏生| 岸本 信康| 松村 正|
抄録  Worldwide, breast cancer accounts for 22.9% of all cancers excluding non-melanoma skin cancers in women. More than 80% of breast cancer cases are discovered when a woman discovers a lump that feels different from the rest of the breast tissue. We report the case of a 60-year-old woman who had been treated for one year at a psychiatric hospital for suspected schizophrenia, and was referred to our hospital on March 23, 2011 for consultation regarding complete blood count abnormalities: hemoglobin, 4.8g/㎗ ; Plt, 1.9×104/μl ; WBC, 12,700/μl with 18.5% abnormal cells. Computed tomography revealed an enhanced, irregular mass in her right breast as well as right axillary lymph node swelling, suggestive of breast cancer. BM biopsy confirmed the presence of abnormal, keratin-positive cells, suggesting metastasis to the bone. CA15-3 was 300U/㎖ (normal range <25). The patient died on April 11, 2011, post-admission day 20. We found a rare case of terminal breast cancer that presented with peripheral blood abnormality. Breast cancer in patients who do not notice breast abnormality can present with peripheral blood abnormality.
キーワード 乳癌(breast cancer) 初発症状(initial symptom) 貧血(anemia) 骨髄転移(bone marrow metastasis)
備考 症例報告 (Case Reports)
出版物タイトル 岡山医学会雑誌
発行日 2014-04-01
126巻
1号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 31
終了ページ 34
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
関連URL http://www.okayama-u.ac.jp/user/oma/
言語 Japanese
著作権者 Copyright (c) 2014 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.126.31
Eprints Journal Name joma
参考文献 1) Kesson EM, Allardice GM, George WD, Burns HJ, Morrison DS : Effects of multidisciplinary team working on breast cancer survival : retrospective, comparative, interventional cohort study of 13 722 women. BMJ (2012) 344, e2718. 2) Bastiaannet E, Liefers GJ, de Craen AJ, Kuppen PJ, van de Water W, Portielje JE, van der Geest LG, Janssen-Heijnen ML, Dekkers OM, van de Velde CJ, Westendorp RG : Breast cancer in elderly compared to younger patients in the Netherlands : stage at diagnosis, treatment and survival in 127,805 unselected patients. Breast Cancer Res Treat (2010) 124, 801-807. 3) Newman LA : Epidemiology of locally advanced breast cancer. Semin Radiat Oncol (2009) 19, 195-203. 4) Lacroix M : Significance, detection and markers of disseminated breast cancer cells. Endocr Relat Cancer (2006) 13, 1033-1067. 5) Braun S, Naume B : Circulating and disseminated tumor cells. J Clin Oncol (2005) 23, 1623-1626. 6) Abdulkareem IH, Zurmi IB : Review of hormonal treatment of breast cancer. Niger J Clin Pract (2012) 15, 9-14. 7) Abramson V, Arteaga CL : New strategies in HER2-overexpressing breast cancer : many combinations of targeted drugs available. Clin Cancer Res (2011) 17, 952-958. 8) Bushe CJ, Bradley AJ, Wildgust HJ, Hodgson RE : Schizophrenia and breast cancer incidence : a systematic review of clinical studies. Schizophr Res (2009) 114, 6-16. 9) Maguire GA : Prolactin elevation with antipsychotic medications : mechanisms of action and clinical consequences. J Clin Psychiatry (2002) 63, 56-62.