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ID 13778
Eprint ID
13778
フルテキストURL
Thumnail 106_779.pdf 2.67 MB
タイトル(別表記)
Insulin-like growth factor binding protein-4 (IGFBP-4) and bone growth in childhood
著者
山中 良孝 岡山大学医学部小児科学教室
抄録
IGFBP-4 is a 24kD protein, originally isolated from the conditioned medium of human bone cells, and has been implicated as a potent inhibitor of IGF action in vitro. To clarify its biological functions in human bone, I measured the serum concentration of IGFBP-4 from patients with endocrinologic disorders, using Western immunoblot. In normal children, IGFBP-4 increased with age. The serum IGFBP-4 levels of patients with GH deficiency and panhypopituitarism were lower than those of normal children. In addition, the serum levels of IGFBP-4 were also significantly lower in children with Turner's syndrome than in the age-matched normal children who were post pubertal. These findings suggest that GH and the sex steroid increase the production of serum IGFBP-4. Then, I examined the influence of GH on the serum level of of IGFBP-4. In the good responders to GH therapy, IGFBP-4 decreased rapidly during the first month, continued to decrease until the third month, and then increased slowly. On the contrary, in the poor responders to GH therapy, the IGFBP-4 level increased until the third month and then remained at a high level. The increased serum IGFBP-4 level may , at least in part, contribute to the low response to GH therapy in the poor responders.
キーワード
Insulin-like growth factor binding protein-4 (IGFBP-4)
Insulin-like growth factor (IGF-Ⅰ)
骨成長
成長ホルモン
性ホルモン
備考
原著
発行日
1994-08
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
106巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
779
終了ページ
787
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/106/7-8/106_7-8_779/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
Copyright© 岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma