タイトル(別表記) The 56th Annual Meeting of the Japanese Society for Clinical Virology
フルテキストURL 127_261.pdf
著者 山田 雅夫|
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
127巻
3号
開始ページ 261
終了ページ 262
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.261
言語 Japanese
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.261
NAID 130005116805
著者 Noda, Yohei| Nishizaki, Kazunori| Yoshinobu, Junko| Orita, Yorihisa| Tsujigiwa, Hidetsugu| Yamada, Masao|
発行日 2013-09
出版物タイトル Acta Oto-laryngologica
133巻
9号
資料タイプ 学術雑誌論文
著者 八代 将登| 塚原 宏一| 松川 昭博| 山田 睦子| 藤井 洋輔| 長岡 義晴| 津下 充| 山下 信子| 伊藤 利洋| 山田 雅夫| 増谷 弘| 淀井 淳司| 森島 恒雄|
発行日 2013-08-01
出版物タイトル 岡山医学会雑誌
125巻
2号
資料タイプ 学術雑誌論文
著者 Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi|
発行日 2013-01
出版物タイトル Critical Care Medicine
41巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32214
フルテキストURL fulltext.pdf
著者 Arao, Yujiro| Hatano, Atsushi| Yamada, Masao| Uno, Fumio| Nii, Shiro|
抄録 <p>In order to elucidate the mechanism of latent infection of herpes simplex virus (HSV), reactivatable latency of three avirulent strains (SKO-1B, -GCr Miyama, SKa) of HSV type 1 was comparatively examined in a mouse latency model. The SKO-1B strain showed high rate of virus reactivation from explanted trigeminal ganglia without n-butyrate enhancement, while the other two strains showed a very low rate of virus reactivation in the absence of n-butyrate. In the presence of n-butyrate, however, the rate of the -GCr Miyama strain jumped to a comparable level with that of SKO-1B, although the rate of SKa remained at a low level. A more precise follow-up experiment changing the virus dose highlighted the difference of the ability to reactivate from the latent state between SKO-1B and -GCr Miyama. Virus titer in trigeminal ganglia during acute phase, infectivity to cell lines of neural origin, and susceptibility to acyclovir and phosphonoacetate were assayed to know the reasons for the variation in the ability of reactivatable latency among these strains. It was concluded that the reduced infectivity to neural cells, and limited ability of reactivatable latency shown by the SKa strain could mainly be attributed to the deficiency of thymidine kinase activity.&#60;/P&#62;</p>
キーワード herpes simplex virus type 1 neurovirulence latency reactivation n-butyrate
Amo Type Article
発行日 1991-02
出版物タイトル Acta Medica Okayama
45巻
1号
出版者 Okayama University Medical School
開始ページ 43
終了ページ 47
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1648298
Web of Sience KeyUT A1991FA75000006
JaLCDOI 10.18926/AMO/32190
フルテキストURL fulltext.pdf
著者 Arao, Yujiro| Hatano, Atsushi| Yamada, Masao| Uno, Fumio| Nii, Shiro|
抄録 <p>Ability of two neurovirulent strains (F and +GC (LPV) Miyama) of herpes simplex virus type 1 (HSV-1) to establish and maintain reactivatable latency in trigeminal ganglia (TG) was compared after intranasal inoculation of mice. The +GC (LPV) Miyama strain showed a very low rate of virus reactivation in explant cultures of TG, while the F strain showed a high rate of reactivation. These data indicate that neurovirulent strains of HSV-1 are not always competent for reactivatable latency, although most virulent strains of HSV-1 thus far reported were competent for reactivatable latency.&#60;/P&#62;</p>
キーワード herpes simplex virus type 1 neurovirulence latency reactivation
Amo Type Article
発行日 1991-04
出版物タイトル Acta Medica Okayama
45巻
2号
出版者 Okayama University Medical School
開始ページ 117
終了ページ 121
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1651044
Web of Sience KeyUT A1991FL60800008
JaLCDOI 10.18926/AMO/32097
フルテキストURL fulltext.pdf
著者 Koirala, Tirtha Raj| Hayashi, Kazuhiko| Jin, Zaishun| Onoda, Sachiyo| Tanaka, Takehiro| Oda, Wakako| Ichimura, Koichi| Ohara, Nobuya| Oka, Takashi| Yamada, Masao| Yoshino, Tadashi|
抄録 <p>Epstein-Barr virus (EBV)-related herpesvirus (Si-IIA-EBV) was serially transmitted for 3 passages from rabbit to rabbit of the opposite sex by blood transfusion, which subsequently induced virus-associated rabbit lymphomas. The virus could be transmitted by transfusion with 15-20 ml of whole blood (7/7) or irradiated blood (1/6) from the EBV-related virus-infected rabbits, but there was no transmission with transfusion of cell-free plasma (0/6) from the infected rabbits. Passive anti-EBV-VCA IgG (x 20 approximately x 10) titers decreased during the first 1-2 weeks in the transfused rabbits. The virus-transmitted rabbits showed a gradual increase in antibody titers ranging from peak titers of x 640 to x 2560 after 3 weeks of transfusion. The recipient origin of malignant lymphoma that developed in the first rabbit transfused by infected blood was confirmed by chromosomal analysis. This rabbit model thus shows that EBV-related herpesvirus is serially transmissible by blood transfusion and that transmission can not be completely prevented by irradiation of blood, but removal of blood cells is the best way to prevent transmission of EBV-related virus. Therefore, this animal model provides a convenient in vivo system for studies of the prevention and therapy of transfusion-related transmission of EBV and EBV-associated lymphoproliferative diseases in immunocompromised human beings.</p>
キーワード ?Epstein-Barr virus(EBV) rabbit lymphoproliferative diseases blood transfusion
Amo Type Article
発行日 2004-04
出版物タイトル Acta Medica Okayama
58巻
2号
出版者 Okayama University Medical School
開始ページ 67
終了ページ 74
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 15255507
Web of Sience KeyUT 000221043700002
著者 山田 雅夫|
発行日 2001-04-28
出版物タイトル 岡山医学会雑誌
113巻
1号
資料タイプ 学術雑誌論文
著者 山田 雅夫|
発行日 1983-03-31
出版物タイトル
資料タイプ 学位論文