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ID 18035
Eprint ID
18035
フルテキストURL
Thumnail 79_485.pdf 3.45 MB
タイトル(別表記)
Study of Distribution of 20-Methylcholanthrene in the Organs of RF Mice Given Repeated Administration of 20-Methylcholanthrene. Part Ⅱ. Organ and Intracellular Distribution of 20-Methylcholanthrene in RF Mice After Repeated Oral Administration
著者
守屋 純一郎 岡山大学医学部平木内科教室
抄録
With the purpose investigating the possible relation between tissue distribution of methylcholanthrene and leukemogenesis, the author measured quantitatively tissue distribution and urinary excretion of methylcholanthrene after oral administration of the carcinogen. Ⅰ) Urinary excretion of methylcholanthrene: The average urinary excretion of methylcholanthrene at every 6, 12, 18, 24, 30 and 36 hours after one oral administration of 0.8% methylcholanthrene olive oil solution was 6.32, 1.95, 1.15, 0.823, 0.415 and 0.153γ, respectively. Ⅱ) Tissue distribution of methylcholanthrene: 0.15 cc of 0.8% methylcholanthrene olive oil solution was administrated orally three times a week. 1) In bone marrow, methylcholanthrene markedly accumulated in comparison mith other tissues from early time of administration. And in thymus and lymph nodes distribution of methylcholanthrene was clearly recognized from about 8 weeks of administration, but not so much as in bone marrow. 2) At 2, 4, 6, 8 and 12 weeks' repeated oral administration, the average methylcholanthrene in bone marrow was 41.9, 67.0, 108, 118 and 238 γ/g respectively. These figures show a tendency of methylcholanthrene accumulation in bone marrow from the second week. Methylcholanthrene in bone marrow increased in proportion to the number of its administration. 3) At 8 weeks' administration the carcinogen detected was 42.1 γ/g in thymus, and 12.4 γ/g in lymph nodes. At 12 weeks' administration its concentration was 83.8 γ/g in thymus, and 38.6 γ/g in lymph nodes. 4) Nuclear and cytoplasmic fractionation studies indicated a much higher concentration of methylcholanthrene in the nuclear fraction of liver and thymus. From these findings, the author wishes to point out a close connection between leukemogenesis of RF mice by oral administration of methylcholanthrene and its tissue distribution in the hematopoietic organs.
発行日
1967-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
79巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
485
終了ページ
498
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/79/5-6/79_5-6_485/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma