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ID 18032
Eprint ID
18032
フルテキストURL
Thumnail 79_465.pdf 4.44 MB
タイトル(別表記)
Study of Distribution of 20-Methylcholanthrene in the Organs of RF Mice Given Repeated Administration of 20-Methylcholanthrene. Part Ⅰ. Distribution of 20-Methylcholanthrene in the Organs of RF Mice After Repeated Skin Painting
著者
守屋 純一郎 岡山大学医学部平木内科教室
抄録
With the purpose of elucidating the action of 20-methylcholanthrene in leukemogenesis in RF mice by painting of 20-methylcholanthrene, the author measured quantitatively the distribution of 20-methylcholanthrene in the organs of mice after repeated painting. The state of excretion of 20-methylcholanthrene in urine after painting was also investigated quantitatively. Ⅰ) Urinary excretion of 20-methylcholanthrene after painting: 0.2 cc of 0.5% benzene solution of 20-methylcholanthrene was painted at the back of mice. The average urinary excretion at 6, 12, 18, 24, 30, 36 hours after painting was 4.16, 2.35, 0.876, 0.360 0.370, and 0.153γ respectively. Ⅱ) Distribution of 20-methylcholanthrene in the organs of mice after repeated painting: 0.2 cc of 0.5% benzene solution of 20-methylcholanthrene was painted at the back of mice twice a week and organ methylcholanthrene was measured quantitatively at 2, 4, 6, 12 and 16 weeks after repeated painting. 1) After 2 week painting, organ methylcholanthrene was too small to be measured in amount, but tended to accumulate in bone marrow. The average tissue distribution of methylcholallthrene after 6 week painting was 137.6 γ/g in bone marrow. 113.4 γ/g in thymus, 61.2 γ/g in lymph nodes, 39.4 γ/g in spleen, 15.3 γ/g in kidney, 14.5 γ/g in heart, 10.3 γ/g in salivary gland and 12.3 γ/g in stomach. 2) After 8 week painting there was a marked increase of methylcholanthrene in bone marrow and thymus, and after 10 and 12 week painting, it further increased. After 16 week painting average tissue distribution of methylcholanthrene was 518 γ/g in bone marrow, 239 γ/g in thymus, 29.7 γ/g in spleen, 44.9 γ/g in lymph nodes, 18.6 γ/g in kidney, 19.7 γ/g in stomach, 19.8 γ/g in salivary gland, and 10.4 γ/g in heart. 3) The state of tissue distribution of methylcholanthrene in C(3)H mice (resistant to leukemia) was almost the same as compared with that of RF mice. From these findings, it was observed that methylcholantrene, when repeatedly, painted in mice accumulated in a higher concentration in bone marrow and thymus than other organs, suggesting an intimate relationship of the carcinogen and target tissues.
発行日
1967-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
79巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
465
終了ページ
483
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/79/5-6/79_5-6_465/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma