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ID 52485
フルテキストURL
タイトル(別表記)
The role of autophagy of early embryonic development in mice
著者
塚本 智史 独立行政法人 放射線医学総合研究所・研究基盤センター・生物研究推進課
抄録
After fertilization, maternal products which are stored during oogenesis are rapidly degraded and newly zygotic products are synthesized in most animals. This transition, known as an oocyte-to-embryo transition, is critical step for further embryonic development. Considering that the process occurs quickly, bulk degradation system could be highly activated to eliminate maternal products and recycle them to synthesize newly products. We have demonstrated that autophagy, which is cytoplasmic bulk degradation system mediated by the lysosome, is highly induced after fertilization, and autophagy-deficient embryo dies before implantation, suggesting that autophagy is essential for preimplantaion embryonic development. Our recent studies also revealed that lysosomal size and number changes during the embryonic development. Here we will briefly review the autophagy, and discuss the function of autophagy and lysosome in early mouse embryogenesis.
備考
特別講演要旨 (Summary of Special Lecture)
発行日
2014-04
出版物タイトル
岡山実験動物研究会報
出版物タイトル(別表記)
Proceedings of Okayama Association for Laboratory Animal Science
30巻
出版者
岡山実験動物研究会
出版者(別表記)
Okayama Association for Laboratory Animal Science
開始ページ
3
終了ページ
6
資料タイプ
その他
言語
Japanese
論文のバージョン
publisher
査読
無し
Eprints Journal Name
poalas