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ID 40501
JaLCDOI
フルテキストURL
著者
Sagara, Hidenori Department of Pharmacy, Okayama University Hospital
Sendo, Toshiaki Department of Pharmacy, Okayama University Hospital
Gomita, Yutaka School of Pharmacy, Shujitsu University
抄録
In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation.
キーワード
intracranial self-stimulation behavior
motivational effect
methamphetamine
nicotine
Amo Type
Review
発行日
2010-10
出版物タイトル
Acta Medica Okayama
64巻
5号
出版者
Okayama University Medical School
開始ページ
267
終了ページ
275
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2010 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT