start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=4
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=200102
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=多価不飽和脂肪酸を２位に結合するホスファチジルコリンの炭素アナローグの合成
kn-title=Synthesis of Carbon Analogues of Phosphatidylcholines Having a Polyunsaturated Fatty Acid at the 2-Position
en-subtitle=
kn-subtitle=
en-abstract=自然界に広く存在するホスフォリパーゼA2はグリセロリン脂質の2位のエステル結合を選択的に切断する酵素であり,消化,アラキドン酸カスケードの起動,リン脂質過酸化物の代謝等,生理作用に広く関わっている。本研究ではホスフォリパーゼA2の基質ミメテイックとしてホスファチジルコリンの2位エステル結合が炭素-炭素結合に置き換わった化合物をアラキドン酸とステアリン酸を出発原料としてリパーゼ触媒によるアシル化反応及び有機化学反応によって合成した。
kn-abstract=Carbon analogues of Phosphatidylcholines having linoleic or arachidonic acid at the 2-position were synthesized. The synthetic route involves conversion of the polyunsaturated fatty acid iodination. The derivatives were converted to diols by LiAIH4 reduction and submitted to lipase-catalyzed monostearoylation in isopropylether. The mono-ester was converted to phoshatidylcholines by the usual phosphodiester synthesis.
en-copyright=
kn-copyright=

en-aut-name=SekiChiyo
en-aut-sei=Seki
en-aut-mei=Chiyo
kn-aut-name=勢喜千代
kn-aut-sei=勢喜
kn-aut-mei=千代
aut-affil-num=1

en-aut-name=MoriYoshihiro
en-aut-sei=Mori
en-aut-mei=Yoshihiro
kn-aut-name=森義裕
kn-aut-sei=森
kn-aut-mei=義裕
aut-affil-num=2

en-aut-name=NakajimaShuhei
en-aut-sei=Nakajima
en-aut-mei=Shuhei
kn-aut-name=中島修平
kn-aut-sei=中島
kn-aut-mei=修平
aut-affil-num=3

en-aut-name=ShimizuSakayu
en-aut-sei=Shimizu
en-aut-mei=Sakayu
kn-aut-name=清水昌
kn-aut-sei=清水
kn-aut-mei=昌
aut-affil-num=4

en-aut-name=BabaNaomichi
en-aut-sei=Baba
en-aut-mei=Naomichi
kn-aut-name=馬場直道
kn-aut-sei=馬場
kn-aut-mei=直道
aut-affil-num=5

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=Division of Applied Bioscience, Graduate School of Agriculture, Kyoto University

affil-num=5
en-affil=
kn-affil=岡山大学
en-keyword=phospholipid
kn-keyword=phospholipid
en-keyword=arachidonic acid
kn-keyword=arachidonic acid
en-keyword=synthesis
kn-keyword=synthesis
en-keyword=phospholipase A2
kn-keyword=phospholipase A2
END