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ID 57894
フルテキストURL
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著者
Oka, Aiko Department of Otorhinolaryngology, International University of Health and Welfare Graduate School of Medicine
Ninomiya, Takahiro Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Fujiwara, Tazuko Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Takao, Soshi Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Sato, Yasuharu Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID researchmap
Gion, Yuka Division of Pathophysiology, Okayama University Graduate School of Health Sciences
Minoura, Akira Department of Hygiene, Public Health and Preventive Medicine, Showa University School of Medicine
Haruna, Shin-ichi Department of Otorhinolaryngology, Head & Neck Surgery, Dokkyo Medical University
Yoshida, Naohiro Department of Otolaryngology, Jichi Medical University Saitama Medical Center
Sakuma, Yasunori Department of Otorhinolaryngology, Yokohama City Medical Center
Izuhara, Kenji Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School
Ono, Junya Shino-Test Co., Ltd.
Taniguchi, Masami Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
Haruna, Takenori Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Higaki, Takaya Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Kariya, Shin Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Koyama, Takahisa Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Takabayashi, Tetsuji Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Imoto, Yoshimasa Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Sakashita, Masafumi Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Kidoguchi, Masanori Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Nishizaki, Kazunori Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Fujieda, Shigeharu Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Okano, Mitsuhiro Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録
Background: Type 2 chronic rhinosinusitis (CRS), especially eosinophilic CRS (ECRS), is an intractable upper airway inflammatory disease. Establishment of serum biomarkers reflecting the pathophysiology of CRS is desirable in a clinical setting. As IgG4 production is regulated by type 2 cytokines, we sought to determine whether serum IgG4 levels can be used as a biomarker for CRS.
Methods: Association between the serum IgG4 levels and clinicopathological factors was analyzed in 336 CRS patients. Receiver operating characteristics (ROC) analysis was performed to determine the cut-off value of serum IgG4 levels that can be used to predict the post-operative recurrence.
Results: Serum IgG4 levels were significantly higher in patients with moderate to severe ECRS versus those with non to mild ECRS. The levels were also significantly higher in asthmatic patients and patients exhibiting recurrence after surgery compared to controls. ROC analysis determined that the best cut-off value for the serum IgG4 level to predict the post-operative recurrence was 95 mg/dL. The corresponding sensitivity and specificity were 39.7% and 80.5%, respectively. When we combined the two cut-off values for the serum IgG4 and periostin, patients with high serum levels of either IgG4 or periostin exhibited a high post-operative recurrence (OR: 3.95) as compared to patients having low serum levels of both IgG4 and periostin.
Conclusions: The present results demonstrate that the serum IgG4 level is associated with disease severity and post-operative course in CRS. In particular, the combination of serum IgG4 and periostin could be a novel biomarker that predicts post-operative recurrence.
キーワード
Chronic rhinosinusitis
Eosinophils
Eosinophils
IgG4
Severity
Surgery
発行日
2020-01-14
出版物タイトル
Allergology International
出版者
Elsevier
ISSN
13238930
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V.
論文のバージョン
publisher
PubMed ID
DOI
関連URL
isVersionOf https://doi.org/10.1016/j.alit.2019.12.004
ライセンス
http://creativecommons.org/licenses/by-nc-nd/4.0/
Citation
Oka A, Ninomiya T, Fujiwara T, et al. Serum IgG4 as a biomarker reflecting pathophysiology and post-operative recurrence in chronic rhinosinusitis [published online ahead of print, 2020 Jan 14]. Allergol Int. 2020;S1323-8930(19)30201-1. doi:10.1016/j.alit.2019.12.004
オープンアクセス(出版社)
OA
オープンアーカイブ(出版社)
非OpenArchive