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ID 17036
Eprint ID
17036
フルテキストURL
Thumnail 91_1579.pdf 1.3 MB
タイトル(別表記)
Induction of erythroblasts in polycythemic rat bone marrow after acute blood letting
著者
中塚 久 岡山大宇医学部第一病理学教室
抄録
Wistar rats were made polycythemic by daily injections of massive numbers of red cells for one week. The injections were made into the peritoneal cavity and the Ht level rose to between 70 and 75%. This plethoric state resulted in suppressed erythropoiesis of the bone marrow. At this stage, a quantity of blood was drawn from the orbital sinuses with concomitant transfusion of a saline-glucose-blood serum mixture. This withdrawal-transfusion process took about 30 minutes and the Ht value decreased from 75 to 25%. Distinct proliferation of erythroblasts and basophilic erythroblasts was observed 6 to 9 hours after blood withdrawal. Polycythemic animals had many large blast-like cells having relatively large clear cytoplasm. In each of these cells, the nucleus had fine chromatin nets and an ambiguous nucleolus. At 3 hours after blood withdrawal proerythroblast like cells with basophilic cytoplasm had appeared, but there were no basophilic erythroblasts. Typical proerythroblasts having characteristic nuclear chromatin nets and deep blue cytoplasm were prominent after 6 to 9 hours. More mature, poly- and orthochromatic erythroblasts appeared between 9 and 12 hours after blood letting. At 72 hours after blood letting, the cytohistologic picture of the bone marrow of polycythemic animals had returned to nearly normal. Possible erythroid cell differentiation from precursors in the bone marrow and from circulating blood is discussed.
キーワード
多血動物
赤芽球分化
骨髄赤芽球前駆細胞
末梢血液幹細胞
発行日
1979-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
91巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1579
終了ページ
1590
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/91/11-12/91_11-12_1579/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma