Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Effects of aging on bronchoalveolar lavage (BAL) cells in patients with asthma

光延 文裕 岡山大学医学部付属病院三朝分院
保崎 泰弘 岡山大学医学部付属病院三朝分院
芦田 耕三 岡山大学医学部付属病院三朝分院
柘野 浩史 岡山大学医学部付属病院三朝分院
岡本 誠 岡山大学医学部付属病院三朝分院
西田 典教 岡山大学医学部付属病院三朝分院
高田 真吾 岡山大学医学部付属病院三朝分院
横井 正 岡山大学医学部付属病院三朝分院
谷崎 勝朗 岡山大学医学部付属病院三朝分院
抄録
Effects of aging and glucocorticoid therapy on bronchoalveolar lavage (BAL) cells, particularly lymphocytes, neutrophils and eosinophils, were examined in 81 patients with asthma. 1. The proportion of BAL lymphocytes tended to increase with aging in asthmatics under age 69 years, and the proportion was significantly higher in patients with asthma between the ages of 60 and 69 than in those under age 39 and between the ages of 40 and 49. 2. The proportions of BAL neutrophils and eosinophils were not related to aging. 3. The proportion of BAL lymphocytes was higher in patients without glucocorticoid therapy than in those with steroid-dependent intractable asthma (SOIA) in those under age 69 years. In patients between the ages of 50 and 59, the proportion of BAL lymphocytes was significantly higher in patients without glucocorticoids than in those with SOIA. 4. The proportion of BAL neutrophils was higher in patients without glucocorticoid therapy than in those with SOIA, and the difference was significant in patients between the ages of 60 and 69. 5. The proportion of BAL eosinophils was not related to glucocorticoid therapy. These results suggest that the proportion of BAL lymphocytes and neutrophils is affected by aging and glucocorticoid therapy, but not BAL eosinophils.
キーワード
aging
asthma
glucocorticoid therapy
BAL cells
ISSN
0918-7839
NCID
AN10430852