Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Basophil reactivity to anti-IgE and calcium ionophore A23187 in patients with bronchial asthma

谷崎 勝朗 岡山大学医学部附属病院三朝分院内科
周藤 眞康 岡山大学医学部附属病院三朝分院内科
貴谷 光 岡山大学医学部附属病院三朝分院内科
河内 和久 岡山大学医学部附属病院三朝分院内科
御舩 尚志 岡山大学医学部附属病院三朝分院内科
奥田 博之 岡山大学医学部附属病院三朝分院産科婦人科
駒越 春樹 岡山大学医学部附属病院第二内科
多田 慎也 岡山大学医学部附属病院第二内科
高橋 清 岡山大学医学部附属病院第二内科
木村 郁郎 岡山大学医学部附属病院第二内科
The release of histamine from basophils induced by anti-lgE and calcium ionophore A 23187 ( Cal) was examined in 27 patients with bronchial asthma and 7 healthy subjects, using a whole blood method. (1)The release of histamine induced by anti-IgE and CaI was significantly higher in atopic asthmatics than in non-atopic cases. (2) The histamine release with anti-lgE and CaI was significantly lower in cases with long-term steroid therapy compared to the release in cases without steroid therapy. (3) The release with anti-lgE and CaI was increased in cases with age of 0-39 years and in cases wpth age at onset of 0-39 years. (4) Anti-IgE induced release correlated to a certain extent with the release induced by CaI. These results show that basophil reactivity as expressed by histamine release changes under different conditions.
Histamine release (ヒスタミン遊離)
Basophils (好塩基球)
Anti-lgE (抗ヒトIgE)
Calcium ionophore A 23187 (カルシウムイオノフォァA23187)
Bronchial asthma (気管支喘息)