Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Basophil histamine release by anti-IgE in Subjects of chronic bronchitis and bronchial asthma

谷崎 勝朗 岡山大学医学部三朝分院内科
周藤 真康 岡山大学医学部三朝分院内科
貴谷 光 岡山大学医学部三朝分院内科
荒木 洋行 岡山大学医学部三朝分院内科
辻 光朗 岡山大学医学部三朝分院内科
高橋 清 岡山大学医学部第2内科
木村 郁郎 岡山大学医学部第2内科
Histamine release from basophils induced by anti-IgE was studied in 8 patients with chronic bronchitis and 50 patients with bronchial asthma by analyzing doseresponse curves. As the result, there were no significant differences in maximum percent histamine release from basophils among three groups of healthy subjects (24.7± 14.2%), patients with chronic bronchitis (27.7±22.1%) and those with bronchial asthma (28.4±17.0%). In the patients with bronchial asthma, the maximum percent histamine release was higher in accordance with higher serum IgE levels, and low maximum percent release was observed in patients with intrinsic asthma (14.1±7.2%). Study of dose-response curves of anti-IgE-induced histamine release showed that a negative slope from E(2) to E(1) was observed in both healthy subjects and patients with chronic bronchitis. The majority of asthmatics with serum IgE levels of 501IU/ml or over showed a positive slope from E(2) to E(1).
Basophil response (好塩基球の反応性)
Anti-lgE (抗ヒトIgE)
Histamine release (ヒスタミン遊離)
chronic bronchitis (慢性気管支炎)
bronchial asthma (気管支喘息)