Condensation of σt -butyl chloroacetate and ketones by means of magnesium in
ether or benzene alone was carried out but the excellent yields of P-hydroxy
ester could not be obtained, and the results of the condensation of t -butyl
bromoacetate and ketones by means of magnesium and mercuric chloride in
benzene were also disappointing.
When a mixture of benzene and ether was used as solvent in the condensation
of t-butyl chloroacetate and ketone in the presence of magnesium and
mercuric chloride, the yields of p-hydroxy esters from cyclohexanone and
methyl isobutyl ketone were 62 and 71 % respectively, and were comparable with
those of other condensing methods.