Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

ヒト胃粘膜ガラクトース転移酵素の研究 第二編 胃潰瘍症例における検討

香川 俊介 岡山大学第一内科学教室 ORCID Kaken ID publons researchmap
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Biopsied specimens of gastric mucosa of normal subjects and patients with gastric ulcer were obtained under routine gastrofiberscopy. UDP-galactosyltransferase activity was measured with the use of ovomucoid as a substrate. In endoscopically normal subjects, UDP-galactosyltransferase activity of the fundic gland area was significantly (p<0.01) higher than that of the pyloric gland area. In ulcer patients without anti-ulcer treatment, UDP-galactosyltransferase activity was elevated in the mucosa surrounding the ulcer at the healing stage and red scarring stage as compared with the corresponding area of non-ulcer individuals. However, under administration of an H(2)-blocker, the change in UDP-galactosyltransferase activity was not observed. These observations may suggest that (1) increased glycoprotein synthses may be a physiological response of the gastric mucosa to the ulcer and may promote ulcer healing, and that (2) the process of the H(2)-blocker induced ulcer healing may not be associated with the apparent increase in glycoprotein synthesis.
gastric ulcer
mucosal glycoprtein
gastric mucosal atrophy
H(2) blocker