Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.


梶原 正行 岡山大学医学部耳鼻咽喉科学教室
Thumnail 96_585.pdf 4.71 MB
Pregnant ddN mice were injected with 15,000 I.U. of water miscible vitamin A intraperitoneally on day 8 of pregnancy. Fetuses were removed surgically on day 18. Twenty of them were selected randomly to be sectioned horizontally and stained with hematoxylin and eosin solution for histological observation of the malformed ossicles. The malleus, incus and stapes were suggested by the observations to have developed directly from branchial arch cartilage: the former two from Meckel's cartilage and the latter from Reichert's cartilage. That the stapes was isolated might lend support to the theory of dual origin of the footplate. The above results were discussed with embryological and bibliographical considerations.
hypervitaminosis A (ビタミンA過剰投与)
mouse fetus (マウス胎仔)
malformed ossicles (耳小骨奇形)