Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

各種刺激物質による肥満細胞の(45)Ca uptakeとCa(2+)拮抗剤

谷崎 勝朗 岡山大学三朝分院内科
駒越 春樹 岡山大学三朝分院内科
周藤 真康 岡山大学三朝分院内科
大谷 純 岡山大学第2内科
貴谷 光 岡山大学第2内科
松香 陽子 岡山大学第2内科
木村 郁郎 岡山大学第2内科
赤木 克己 クレイトン大学内科
Townley Robert G. クレイトン大学内科
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抄録
(45)Ca uptake by rat peritoneal mast cells was observed, and the inhibitory effect of nifedipine, a Ca(2+) antagonist, on (45)Ca uptake by mast cells, stimulated by an antigen, comp. 48/80, concanavalin A and Ca ionophore A 23187, was examined. The increase in (45)Ca uptake by mast cells induced by the antigen paralleled the increase in mast cell number. A significant increase in the uptake of (45)Ca by mast cells was observed with the stimulation by the antigen, comp. 48/80, concanavalin A and Ca ionophore A 23187. The increased uptake of (45)Ca induced by antigen was inhibited by nifedipine, and this dose-dependent inhibitory effect of nifedipine on (45)Ca uptake was also observed in the mast cells stimulated by comp. 48/80, concanavalin A and Ca ionophore A 23187.
キーワード
肥満細胞
(45)Ca uptake
Ca(2+)拮抗剤
ISSN
0030-1558
NCID
AN00032489