Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

抗腫瘍抗体結合Neocarzinostatin(NCS)による免疫化学療法の研究 第2編 抗体結合Neocarzinostatin(NCS-immune IgG)の生物学的活性の検討

古林 太加志 岡山大学医学部第2内科
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抄録
Anti-NALL-1 rabbit IgG was incubated with NCS, an unique membrane-reactive anticancer antibiotic, in the presence of water-soluble carbodiimide. The resulting mixture contained NCS-immune IgG. The conjugates inhibited the growth and (3)H-TdR incorporation of human leukemia cell line (NALL-1) cells. A membrane immunofluorescent test with FITC-labeled rabbit anti-NCS and goat anti-rabbit IgG antibodies showed specific localization of NCS-immune IgG on NALL-1 cell surfaces. These results indicate that NCS-immune IgG retains both NCS and antibody activities, and NCS-immune IgG should be useful for cancer therapy.
キーワード
免疫化学療法
抗腫瘍抗体結合抗癌剤
Neocarzinostatin
ISSN
0030-1558
NCID
AN00032489