Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

成人T細胞性白血病(Adult T-cell leukemia)に関する研究 第1編 白血病細胞の抗原性

十川 重次郎 岡山大学医学部第2内科教室
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The antigenic properties of leukemic cells from five patients with adult T-cell leukemia were studied with rabbit anti-MOLT-4 and anti-human thymocyte antisera using indirect membrane immunofluorescent staining. The E rosette-positive, surface immunoglobulin (sIg) negative leukemic cells from these patients gave a positive reaction with appropriately absorbed antisera, which reacted specifically with thymocytes, cells from T-cell acute lymphoblastic leukemia (T-ALL) and T-ALL derived lymphoblastoid cell lines (T-LCLs) and normal fresh peripheral T-cells. Nevertheless, antisera further absorbed with fresh peripheral blood lymphocytes (FN-PBL) lost almost all reactivity with the leukemic cells as well as with normal peripheral blood T-cells but still retained reactivity with thymocytes, T-LCLs and T-ALL cells. The results suggest that adult T-cell leukemic cells possess a mature T-cell antigen but not a thymus-specific antigen.
Adult T-cell leukemia
Thymus-specific antigen
Mature T-cell antigen