Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

呼吸器アレルギーにおける肺の組織学的研究 第1編 アレルギー性呼吸器疾患における生検肺の組織学的検討

原田 寛 岡山大学医学部第2内科学教室
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抄録
Histological investigations of lung specimen and bronchial membrane from patients with bronchial asthma and hypersensitivity pneumonitis were performed by the technique of transbronchoscopic biopsy. The results are summarized as follows. 1) Histological changes such as interstitial and peribronchiolar mononuclear cell infiltration, and septal thickening were observed in lung specimens from patients with bronchial asthma. Histological changes of bronchial membrane were also observed in these cases. 2) In patients with bronchial asthma, histological changes in bronchiolar-alveolar regions were closely related to age, positive immediate skin reaction and precipitin to Candida, serum IgE level and micronodular shadow on chest X-ray film. The degree of histological changes in segmental bronchus were related to age at onset and positive immediate, late, and delayed skin reaction to Candida. Asthmatic patients with marked histological changes in segmental bronchus showed more decreasing ratio of FVC, FEV 1.0%, MMF, V50 and V25 than the other cases. 3) Granulomatous change in one case and Masson body in another were observed, alveolitis in three and peribronchiolar cell infiltration in four of five patients with hypersensitivity pneumonitis.
キーワード
経気管支鏡的肺生検
肺胞細気管支領域
区域気管支
気管支喘息
過敏性肺臓炎
ISSN
0030-1558
NCID
AN00032489