1) The frequency and microscopic morphology of senile changes are compared, in frontal cut Bodian preparations, in two cases of progressive supranuclear palsy (ages 62 and 71) and 14 control senile brains (between the ages of 70 and 91). 2) Neurofibrillary tangles were found in all the control brains with a predilection for hippocampal areas. Senile plaques were found in 86 per cent of all the control cases. Most were small and primitive, with great individual variations in frequency. The numbers of neurofibrillary tangles and of senile plaques did not correlate, but rather were dissociated. No relation was found between the number of tangles and/or senile plaques and the ages of the control patients. 3) Two cases of progressive supranuclear palsy showed no senile plaques. Neurofibrillary tangles were more numerous than in the control senile cases. Tangles were found in the outer and middle layers of the cerebral cortex and in the pontine basis. In Bodian prepa rations, most were black, presenting fine tangles with string and mesh forms. The nucleus and cell plasma were preserved in contrast to senile brains. But in the hippocampal areas, differences in form were not observed between tangles of progressive supranuclear palsy and control brains.
Progressive supranuclear palsy
Neurofibrillary tangles in the cerebral cortex