Journal of Okayama Medical Association
Published by Okayama Medical Association

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マウス脳内guanidino化合物に関する研究 第2編 けいれんにともなう脳内guanidino化合物の変動について

平松 千明 岡山大学医学部脳代謝研究施設機能生化学部門
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抄録
1. Brain guanidino compound levels in ddY mice were analysed in the pre-convulsive stage, during convulsion and at the post-convulsive stage of convulsive seizures induced by pentylenetetrazol or electric stimulation. 2. Significantly increased levels of taurocyamine was found in the pre-convulsive stage, just after pentylenetetrazol injection. This recovered temporarily to normal levels during convulsion, though the level increased again in the post-convulsive stage. Marked increases in creatinine were observed throughout the convulsive seizure induced by pentylenetetrazol; i.e. in the pre-convulsive stage, during convulsion and in the post-convulsion stage. 3. Significantly decreased levels of taurocyamine were found during electrically induced convulsions. Increased levels of creatinine were found in the pre-convulsive stage.
キーワード
Guanidino化合物
発作機序
Pentylenetetrazol けいれん
電気刺激けいれん
ISSN
0030-1558
NCID
AN00032489