Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

全身性エリテマトーデスにおける抗細胞質抗体の検索 (蛍光抗体法を中心として)

村上 幹郎 岡山大学第三内科
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抄録
By the indirect fluorescent antibody technique, sera of patients with systemic lupus erythematosus were used to stain the cytoplasm of proximal tubule cells of rat kidney frozer sections and the cytoplasm of cells in frozen sections of rat liver. Since the cytoplasmic stainings of rat liver were absorbed with ribosomes and the stainings of proximal tubules were absorbed with mitochondria, the sera were thought to contain either anit-ribosomal antibodies or anti-mitochondrial antibodies. By Ouchterlony methods, some sera produced precipitin lines against 105,000 G supernatant of rat liver homogenate distinct from the ribosomal system. This antigen activity was present in the first peak of a Sephadex G-100 column chromatograph.
キーワード
全身性エリテマトーデス(SLE)
抗細胞質抗体
抗ミトコンドリア抗体
抗リボゾーム抗体
105,000G上清成分
ISSN
0030-1558
NCID
AN00032489