Journal of Okayama Medical Association
Published by Okayama Medical Association

<Availability>
Full-text articles are available 3 years after publication.

四塩化炭素肝障害ラットにおける1-(2-Tetrahydrofuryl)-5-fluorouracilの血中消失速度定数に及ぼす還元型グルタチオンとビタミンEの影響

芳原 準男 岡山大学医学部第一内科教室
渡辺 明治 岡山大学医学部第一内科教室
長島 秀夫 岡山大学医学部第一内科教室
Thumnail 92_267.pdf 237 KB
抄録
The pharmacokinetics of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) were analysed by measuring its disappearance rate (K) from the circulating blood using a high-pressure liquid chromatographic technique. An increase in the disappearance rate of FT was observed by treatment with reduced glutathione (GSH)- or tocopheryl nicotinate-treated rats. The clearance rates of FT from the circulating blood in carbon tetrachloride (CCl(4))-injured rats were much smaller than those in untreated rats. The unresponsiveness of K values to treatment with GSH or tocopheryl nicotinate was seen in liver-injured rats.
キーワード
四塩化炭素肝障害
FT
ビタミンE
還元型グルタチオン
血中消失速度定数
ISSN
0030-1558
NCID
AN00032489