Journal of Okayama Medical Association
Published by Okayama Medical Association

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ポリ塩化ナフタリン(PCN)中毒に関する実験的研究 第1報 PCNの正常ラツト肝ミトコンドリアの酸化的リン酸化に対する作用

大熊 勝明 岡山大学医学部公衆衛生
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抄録
Effect of PCNs on normal isolated mitochondrial membrane was studied and the results obtained were as follows. 1) PCNs inhibited the state 3 respiration, and stimulated the state 4 respiration (namely uncoupling action). 2) The proportional relationship between a decrease in RCI and an increase in concentration of Halowax 1001 (PCN) was recognized, and a decrease tendency of ADP/O ratio was observed within the range of PCN concentration measured. 3) PCNs induced a K(+) release in mitochondria and the release effect was the strongest in Halowax 1031 (PCN). 4) Discussion was made that effects of PCNs on the mitochondrial membrane were seemed to be related to their complex characters which are the content of chlorine and their isomers.
キーワード
ポリ塩化ナフタリン
酸化的リン酸化
呼吸活性
K(+)遊出
ISSN
0030-1558
NCID
AN00032489