I discussed on the lymphnode metastasis and prognosis of 134 cases of breast cancer patients from the stand points of hormonal circumstances in this paper. 17-Ketosteroids and 17-hydroxycorticosteroids were checked as urinary steroids. α-and β-globulins were considered as steroid binding substance groups. These factors analyzed comparing with lymphnode metastasis and prognosis of patients with breast cancer. The favorable hormonal circumstances were as follows; 17-KS≧3mg, 17-OHCS≧2mg/day, α-gl.<13%, and β-gl.>11%. Patients in favorable circumstances have good prognosis, and react for therapies even in advanced and recurrent cases. The poor hormonal circumstances for breast cancer patients were as follows; 17-KS<3mg, 17-OHCS<2mglday, α-gl.≧13%, and β-gl.≧11%. The patients in poor circumstances have poor prognosis, and not react for therapies in advanced and recurrent cases.