Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

肺癌に関する研究 第2編 Bleomycinによる原発性肺癌(進行癌)及び転移性肺腫瘍の治療

高野 純行 岡山大学医学部平木内科
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Twenty-four cases of lung cancer, mainly of advanced cases and seven cases of metastatic lung tumors were treated with Bleomycin in combination with fibroblast-inhibiting agents such as chloroquine, phytonadione and prednisolone, and following results were obtained. 1) Of 24 lung cancers, 14 cases were evaluated by the chemotherapy evaluation standard adopted by the Japan Society For Cancer Therapy and "improvement" in 4 cases, "no change" in 8 cases and "aggravation" in 2 cases. The effects evaluated with histlogical types included "improvement" in 2 cases of 4 epidermoid carcinomas, but "no improvement" in adenocarcinomas and in undifferentiated carcinomas. 2) Of 7 metastatic lung tumors, 4 cases were evaluated, and "improvement" was obtained in a case of uterus carcinoma origin. 3) The side effects of Bleomycin were changes of skin such as pigmentation or sklerosis in 7 cases, phlebitis, fever and pulmonary disorder in 3 cases each, epilation and anorexia in 2 cases and stomatitis in 1 case. Of these side effects, pulmonary disorder must be paid careful attention and early detection of its occurrence is required and combination of fibroblast-inhibiting agents is believed necessary for the prevention of its occurrence.