Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

Methylcholanthrene投与後発癌過程における宿主の免疫系ないしは生体防禦機構について

寺田 紀彦 岡山大学医学部第一外科教室
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抄録
On the administration of methylcholanthrene (MCA) to mice there can be observed a decrease in the plaque forming cells (PFC) from early stage, and in the post-administration week 5, at the time considered to be of precancerous stage the decrease in PFC number is most marked, being at the minimal level of 55.6% as compared with that of the control (untreated mice). In other words, the administration of MCA reduces the PFC number of spleen cells in mice and it markedly suppresses the immunological activity of normal mice. This indicates that MCA is appreciably involved in the immunity to carcinogenesis. On the other hand, the activity of allogeneic inhibition in the precancerous stage is maintained during the period between MCA administration and the time of cancer development. However, the allogeneic inhibition activity decreases by 8 weeks after MCA administration, the time when the tumor has grown to the size macroscopically visible. This finding suggests that the activity of the allogeneic inhibition is associated more with the proliferation rather than with oncogenesis.
ISSN
0030-1558
NCID
AN00032489