Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

SV40DNAによるマウス胎児培養細胞の試験管内発癌について

山本 晋一郎 岡山大学医学部癌研生化学
江草 国之 岡山大学医学部癌研生化学
小田 琢三 岡山大学医学部癌研生化学
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抄録
The oncogenicity of SV 40 DNA was examined in mouse embryo cell cultures in vitro. T antigen induction in mouse embryo cells by SV 40 DNA was predominant at 5 days after infection and T antigen positive cells were observed by more than 10% at this stage. They decreased with increasing time until about 30 to 50 days of culture, after which numbers of cells with positive T antigen increased again to 36 to 38% with morphological changes accompanied. Morphological alterations seen at about 100 days after infection were characteristic of SV 40 transformed cells, e.g., criss-cross appearance, giant cell formation and irregurality of cell arrangements.
ISSN
0030-1558
NCID
AN00032489