In order to investigate the effectiveness of the chemical protective agents against mice and rabbits doubly stressed by uranium administration and gamma irradiation as reported in Study 1, Ca-EDTA and Cysteine were used as the agent.
For mice irradiated 650r gamma ray on whole body after 10mgU/kg intraperitoneal injection of uranyl nitrate, Cysteine (100mg/kg, 200mg/kg, 400mg/kg, respectively) was intraperitoneally injected 10-15min. before the treatment, or Ca-EDTA of the same above doses after 2hr. The double effect of Cysteine and Ca-EDTA was examined also.
For rabbits irradiated 800r gamma ray on whole body after 0.2mgU/kg intravenous injection of uranyl nitrate, Cysteine 50mg/kg were intravenously injected 10-15min. before the treatment, or Ca-EDTA 50mg/kg after 2hr. The double effect of Cysteine and Ca-EDTA was examined also.
On mortality rate, and kidney histology of mice, none protein nitrogen of blood of rabbits, Ca-EDTA was effective while Cysteine was uot showed any recognizable effect, nor the combination of Ca-EDTA and Cysteine, too.