Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

ep系マウスの病態生理に関する実験的研究 第2編 ep系マウスの脳波ならびに各種抗痙攣剤のこれにおよぼす影響について

杉生 了亮 岡山大学医学部第1(陣内)外科教室
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An attempt was made to find out the effect of anticonvulsive agents such as diphenylhydantoin, phenobarbital and homocarnosine (γ-aminobutyryl-L-histidine) on the abnormal resting potentials of the ep-mouse. 1. Bilateral and sporadic spikes were noted to be characteristic abnormal potentials in the resting E. E. G. of the ep-mouse comparing with the one of the control, the CF-1 group. It was observed in 95% of the ep-mouse. 2. The spikes were found to be inhibited by the administration of phenobarbital: the absolute abolishment was obtained with 12 day successive administration of the 50~60mg/kg/day. 3. Such inhibition was also obtained by the administration of diphenylhydantoin: the absolute abolishment was obtained with 15 day successive administration of the 120~130mg/kg/day. 4. So was found in case of homocarnosine intracerebrospinal administration. The absolute abolishment of the spikes was found after the 7th post-administration day includingly. 5. The abolishment of the abnormal spike potential by these anticonvulsive agents was preceded by inhibition of convulsion.