Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

γ-アミノ酪酸の代謝に関する研究 第2編 てんかん脳切片による(14)C-γ-Aminobutyric aicdの代謝について

宇野 和昌 岡山大学医学部第1(陣内)外科教室
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抄録
Studies were carried out to clearfy GABA metabolism in the brains of an epileptic, the latent cerebral local anaphylactic (L. C. L. A.) rabbit and ep-mouse administered with (14)C-GABA. 1) Incubated with a brain slice, radioactivity of (14)C-GABA was slightly detected in glutamic acid, aspartic acid and glutamine in the incubation medium. 2) In this case, most of the radioactive carbon of GABA was converted into (14)CO(2). 3) The epileptic brain appeared to decreased in the (14)CO(2)-activity, compared with the non-epileptic. In case of the epileptic brain, the activity in the focus was lower than the one in the non-focus. 4) The study with L. C. L. A. rabbit and ep-mouse could not manifest any difference in GAGA metabolism in contrast to the normal control groups.
ISSN
0030-1558
NCID
AN00032489